SWIP Strumpellin and WASH-interacting protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: SWIPprovided by FlyBase
Official Full Name: Strumpellin and WASH-interacting proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0030739
Locus tag: Dmel_CG13957
See related: AllianceGenome:FB:FBgn0030739
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13957; Dmel\CG13957; KIAA1033; p116; swip
Summary: Involved in nuclear envelope budding and positive regulation of cell adhesion. Located in nucleoplasm. Part of WASH complex. Colocalizes with nuclear envelope. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 43. Orthologous to human WASHC4 (WASH complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (16313709..16317750)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (16207742..16211783)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in endosomal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosomal transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in endosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear envelope budding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of WASH complex	IBA Inferred from Biological aspect of Ancestor more info
part_of WASH complex	IDA Inferred from Direct Assay more info	PubMed
part_of WASH complex	IEA Inferred from Electronic Annotation more info
part_of WASH complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain