HINT1 histidine triad nucleotide binding protein 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: HINT1provided by FlyBase
Official Full Name: histidine triad nucleotide binding protein 1provided by FlyBase
Primary source: FLYBASE:FBgn0031459
Locus tag: Dmel_CG2862
See related: AllianceGenome:FB:FBgn0031459
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2862; Dmel\CG2862
Summary: Predicted to enable adenosine 5'-monophosphoramidase activity. Predicted to be involved in purine ribonucleotide catabolic process. Predicted to be active in mitochondrial matrix and nucleus. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in Gamstorp-Wohlfart syndrome. Orthologous to human HINT1 (histidine triad nucleotide binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 23A5-23A5; 2-7 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (2770135..2770904)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (2770135..2770904)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables adenosine 5'-monophosphoramidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in purine ribonucleotide catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: histidine triad nucleotide binding protein 1

Names: CG2862-PA; CG2862-PB; CG2862-PC; HINT1-PA; HINT1-PB; HINT1-PC

NP_001259964.1

EC 3.-.-.-

NP_608711.3

EC 3.-.-.-

NP_722836.1

EC 3.-.-.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

2770135..2770904

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_134867.4 → NP_608711.3 histidine triad nucleotide binding protein 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608711.3

Status: REVIEWED

UniProtKB/TrEMBL

Q8STA5, Q9VQG5

Related

FBpp0077402

Conserved Domains (1) summary

cd01276
Location:40 → 142

PKCI_related; Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a ...
NM_001273035.1 → NP_001259964.1 histidine triad nucleotide binding protein 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259964.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8STA5, Q9VQG5

Conserved Domains (1) summary

cd01276
Location:40 → 142

PKCI_related; Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a ...
NM_164500.2 → NP_722836.1 histidine triad nucleotide binding protein 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722836.1

Status: REVIEWED

UniProtKB/TrEMBL

Q86BQ4

Related

FBpp0077403

Conserved Domains (1) summary

cd01276
Location:16 → 118

PKCI_related; Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a ...