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    drm drumstick [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49638, updated on 9-Dec-2024

    Summary

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    Official Symbol
    drmprovided by FlyBase
    Official Full Name
    drumstickprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024244
    Locus tag
    Dmel_CG10016
    See related
    AllianceGenome:FB:FBgn0024244
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10016; Dmel\CG10016; drum
    Summary
    Involved in digestive tract morphogenesis; embryonic pattern specification; and imaginal disc-derived leg joint morphogenesis. Is expressed in several structures, including anlage in statu nascendi; epithelial cell; epithelium; gut section; and visceral mesoderm derivative. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See drm in Genome Data Viewer
    Location:
    24A1-24A1; 2-10 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3539247..3548423)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3539247..3548423)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Intraflagellar transport 57 Neighboring gene long non-coding RNA:CR44308 Neighboring gene long non-coding RNA:CR44309 Neighboring gene long non-coding RNA:CR44747

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. lines and bowl affect the specification of cyst stem cells and niche cells in the Drosophila testis. Dinardo S, et al. Development, 2011 May. PMID 21486923, Free PMC Article
    2. Intestinal alkaline phosphatase targets the gut barrier to prevent aging. Kühn F, et al. JCI Insight, 2020 Mar 26. PMID 32213701, Free PMC Article
    3. Curled encodes the Drosophila homolog of the vertebrate circadian deadenylase Nocturnin. Grönke S, et al. Genetics, 2009 Sep. PMID 19581445, Free PMC Article
    4. How to make stripes: deciphering the transition from non-periodic to periodic patterns in Drosophila segmentation. Schroeder MD, et al. Development, 2011 Jul. PMID 21693522, Free PMC Article
    5. Identification of evolutionarily conserved downstream core promoter elements required for the transcriptional regulation of Fushi tarazu target genes. Shir-Shapira H, et al. PLoS One, 2019. PMID 30998799, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. drm is activated under the control of tll and triggers development of the small intestine cell-non-autonomously through some extracellular signaling
      Title: The drumstick gene acts cell-non-autonomously and triggers specification of the small intestine in the Drosophila hindgut.
    2. Drm and Lines regulate Bowl protein accumulation and consequent patterning in the epithelia of the foregut, hindgut, and imaginal discs.
      Title: The Drumstick/Lines/Bowl regulatory pathway links antagonistic Hedgehog and Wingless signaling inputs to epidermal cell differentiation.
    3. data show that drm encodes a zinc finger protein that is a member of the Odd-skipped family; drm expression is localized to the developing midgut-hindgut junction, while lines is broadly expressed throughout the gut primordium.
      Title: Drumstick is a zinc finger protein that antagonizes Lines to control patterning and morphogenesis of the Drosophila hindgut.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in digestive tract development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in embryonic foregut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic hindgut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in foregut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hindgut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived leg joint morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    drumstick
    Names
    CG10016-PA
    CG10016-PB
    CG10016-PC
    drm-PA
    drm-PB
    drm-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3539247..3548423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080527.3 → NP_536788.2  drumstick, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_536788.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V041, Q49UC1, Q8SZH7, Q9VQS6
      UniProtKB/TrEMBL
      A0A1B2AJP0
      Related
      FBpp0077219
      Conserved Domains (1) summary
      sd00017
      Location:28 → 48
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_164545.2 → NP_722921.1  drumstick, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722921.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V041, Q49UC1, Q8SZH7, Q9VQS6
      UniProtKB/TrEMBL
      A0A1B2AJP0
      Related
      FBpp0077220
      Conserved Domains (1) summary
      sd00017
      Location:28 → 48
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001298661.1 → NP_001285590.1  drumstick, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285590.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JD31
      Conserved Domains (1) summary
      sd00017
      Location:28 → 48
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQS6.2 Q9VQS6
    X2JD31 X2JD31

    Gene LinkOut

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    Other Literature Sources
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