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    Phae2 Phaedra 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34638, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Phae2provided by FlyBase
    Official Full Name
    Phaedra 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0263235
    Locus tag
    Dmel_CG16997
    See related
    AllianceGenome:FB:FBgn0263235
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG16997; Dmel\CG16997; SP147
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Phae2 in Genome Data Viewer
    Location:
    33C4-33C4; 2-46 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12111110..12112256)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12111110..12112256)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Rab6 Neighboring gene Phaedra 1 Neighboring gene uncharacterized protein Neighboring gene rhomboid-6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The developmental role of warthog, the notch modifier encoding Drab6. Purcell K, et al. J Cell Biol, 1999 Aug 23. PMID 10459009, Free PMC Article
    2. Role of elongator subunit Elp3 in Drosophila melanogaster larval development and immunity. Walker J, et al. Genetics, 2011 Apr. PMID 21288872, Free PMC Article
    3. Comparative transcriptome analysis reveals a potential mechanism for host nutritional manipulation after parasitization by Leptopilina boulardi. Zhou S, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2021 Sep. PMID 34120097
    4. Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies. Nakano S, et al. PLoS Genet, 2023 Jun. PMID 37319131, Free PMC Article
    5. Functional screening of mammalian mechanosensitive genes using Drosophila RNAi library- Smarcd3/Bap60 is a mechanosensitive pro-inflammatory gene. Kumar S, et al. Sci Rep, 2016 Nov 7. PMID 27819340, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phaedra 2
    Names
    CG16997-PB
    CG16997-PC
    Phae2-PB
    Phae2-PC
    Phaedra2
    NP_001285871.1
    NP_609551.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12111110..12112256
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298942.1 → NP_001285871.1  phaedra 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285871.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V404, Q9VKA8
      Conserved Domains (2) summary
      smart00020
      Location:31 → 259
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:32 → 262
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_135707.3 → NP_609551.2  phaedra 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609551.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V404, Q9VKA8
      Conserved Domains (2) summary
      smart00020
      Location:31 → 259
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:32 → 262
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKA8 Q9VKA8

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