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    CG42319 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36473, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG42319provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259219
    Locus tag
    Dmel_CG42319
    See related
    AllianceGenome:FB:FBgn0259219
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17041; CG17042; Dmel\CG42319
    Old locus tag
    Dmel_CG17041; Dmel_CG17042
    Summary
    Predicted to enable actin binding activity and muscle alpha-actinin binding activity. Predicted to be involved in actin cytoskeleton organization and muscle structure development. Predicted to be part of filamentous actin. Predicted to be active in Z disc; adherens junction; and stress fiber. Is expressed in dorsal head epidermis; dorsal pharyngeal muscle cell; embryonic brain; larval muscle system; and larval somatic muscle cell. Orthologous to human PDLIM2 (PDZ and LIM domain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG42319 in Genome Data Viewer
    Location:
    49F13-49F15; 2-68 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13260101..13266336)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9147606..9153841)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Diuretic hormone 31 Receptor Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response. Zinke I, et al. EMBO J, 2002 Nov 15. PMID 12426388, Free PMC Article
    2. An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination. Kanca O, et al. Elife, 2022 Jun 20. PMID 35723254, Free PMC Article
    3. Comprehensive Identification and Alternative Splicing of Microexons in Drosophila. Pang TL, et al. Front Genet, 2021. PMID 33859668, Free PMC Article
    4. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Hosono C, et al. Nat Cell Biol, 2015 Dec. PMID 26551273
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables muscle alpha-actinin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle structure development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of filamentous actin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42319-PA
    CG42319-PB
    CG42319-PC
    CG42319-PD
    CG42319-PE
    CG42319-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13260101..13266336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144176.2 → NP_001137648.1  uncharacterized protein Dmel_CG42319, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137648.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZE5
      Conserved Domains (1) summary
      cd00992
      Location:45 → 119
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    2. NM_001103831.3 → NP_001097301.1  uncharacterized protein Dmel_CG42319, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097301.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A2RVI0
      Conserved Domains (1) summary
      cd00992
      Location:45 → 119
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    3. NM_137017.3 → NP_610861.2  uncharacterized protein Dmel_CG42319, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610861.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9B6, Q058Z0

    4. NM_165977.3 → NP_725274.1  uncharacterized protein Dmel_CG42319, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725274.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K076
      Related
      FBpp0289015

    5. NM_137016.4 → NP_610860.2  uncharacterized protein Dmel_CG42319, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610860.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K076
      Related
      FBpp0289014

    6. NM_165978.2 → NP_725275.1  uncharacterized protein Dmel_CG42319, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725275.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K076
      Related
      FBpp0289016
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2RVI0 A2RVI0
    B7YZE5 B7YZE5
    Q058Z0 Q058Z0
    Q7K076 Q7K076

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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