GlyT Glycine transporter [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: GlyTprovided by FlyBase
Official Full Name: Glycine transporterprovided by FlyBase
Primary source: FLYBASE:FBgn0034911
Locus tag: Dmel_CG5549
See related: AllianceGenome:FB:FBgn0034911
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5549; dGlyT; Dmel\CG5549
Summary: Enables glycine:sodium symporter activity and neurotransmitter:sodium symporter activity. Involved in glycine import across plasma membrane; neurotransmitter transport; and regulation of circadian rhythm. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult abdomen; adult head; and adult thorax. Human ortholog(s) of this gene implicated in hyperekplexia 3 and obesity. Orthologous to several human genes including SLC6A5 (solute carrier family 6 member 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (23820354..23839864)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19707877..19727387)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables glycine:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glycine:sodium symporter activity	ISM Inferred from Sequence Model more info	PubMed
enables neurotransmitter transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables neurotransmitter:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in amino acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycine import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in glycine transport	ISM Inferred from Sequence Model more info	PubMed
involved_in neurotransmitter transport	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain