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    CG11406 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37877, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG11406provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034990
    Locus tag
    Dmel_CG11406
    See related
    AllianceGenome:FB:FBgn0034990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG11406
    Summary
    Predicted to enable triacylglycerol lipase activity. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 8. Orthologous to human LIPK (lipase family member K); LIPM (lipase family member M); and LIPN (lipase family member N). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11406 in Genome Data Viewer
    Location:
    60C2-60C2; 2-106 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24202091..24208203, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20089614..20095726, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene over compensating males Neighboring gene cytosolic 5'-nucleotidase IIIB Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44827

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Paucity of chimeric gene-transposable element transcripts in the Drosophila melanogaster genome. Lipatov M, et al. BMC Biol, 2005 Nov 12. PMID 16283942, Free PMC Article
    2. A Genetic Screen Using the Drosophila melanogaster TRiP RNAi Collection To Identify Metabolic Enzymes Required for Eye Development. Pletcher RC, et al. G3 (Bethesda), 2019 Jul 9. PMID 31036678, Free PMC Article
    3. A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster. Kumar K, et al. Biochemistry, 2021 Apr 27. PMID 33827210, Free PMC Article
    4. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11406-PA
    CG11406-PB
    CG11406-PC
    CG11406-PD
    NP_001014548.1
    NP_001163290.1
    NP_001286832.1
    NP_611897.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24202091..24208203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014548.2 → NP_001014548.1  uncharacterized protein Dmel_CG11406, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014548.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59E63
      Conserved Domains (3) summary
      pfam00561
      Location:67 → 371
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam04083
      Location:28 → 85
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:67 → 203
      Abhydrolase_5; Alpha/beta hydrolase family

    2. NM_138053.4 → NP_611897.2  uncharacterized protein Dmel_CG11406, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611897.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W195
      Conserved Domains (3) summary
      pfam00561
      Location:2 → 301
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam12695
      Location:245 → 295
      Abhydrolase_5; Alpha/beta hydrolase family
      cl21494
      Location:2 → 110
      Abhydrolase; alpha/beta hydrolases

    3. NM_001169819.2 → NP_001163290.1  uncharacterized protein Dmel_CG11406, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163290.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JGW0, Q3KN49
      Conserved Domains (1) summary
      cl21494
      Location:2 → 110
      Abhydrolase; alpha/beta hydrolases

    4. NM_001299903.1 → NP_001286832.1  uncharacterized protein Dmel_CG11406, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286832.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JGW0, Q3KN49
      Conserved Domains (1) summary
      cl21494
      Location:2 → 110
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JGW0 E1JGW0
    Q59E63 Q59E63
    Q9W195 Q9W195

    Gene LinkOut

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