RhoGEF64C Rho guanine nucleotide exchange factor at 64C [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: RhoGEF64Cprovided by FlyBase
Official Full Name: Rho guanine nucleotide exchange factor at 64Cprovided by FlyBase
Primary source: FLYBASE:FBgn0035574
Locus tag: Dmel_CG32239
See related: AllianceGenome:FB:FBgn0035574
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13709; CG13710; CG32239; Dmel\CG32239; EP(3)3035; EP3035; GEF; GEF(64C); Gef64C; GEF64C; RhoGEF; RhoGEF64; RhoGef64C
Summary: Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including imaginal disc-derived leg morphogenesis; positive regulation of Rho protein signal transduction; and spiracle morphogenesis, open tracheal system. Located in apical cortex. Is expressed in several structures, including Malpighian tubule tip cell primordium; centripetal follicle cell; embryonic Malpighian tubule tip cell; epithelium; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (4692783..4796253)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (4692783..4796253)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rho protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in spiracle morphogenesis, open tracheal system	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in apical cortex	IDA Inferred from Direct Assay more info	PubMed

Names: CG32239-PA; CG32239-PB; Rho guanine nucleotide exchange factor; RhoGEF64C-PA; RhoGEF64C-PB; guanine nucleotide exchange factor; guanine nucleotide exchange factor 64C; guanine nucleotide exchange factor GEF64C

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