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    NPFR Neuropeptide F receptor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40754, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NPFRprovided by FlyBase
    Official Full Name
    Neuropeptide F receptorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037408
    Locus tag
    Dmel_CG1147
    See related
    AllianceGenome:FB:FBgn0037408
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0131005.3; anon-WO0131005.5; CG1147; Dmel\CG1147; DmNPFR1; dNPFR1; Drm-NPFR; NPF R; NPF receptor; NPF-R; NPF-R1; npfr; NPFr; NPFR-1; npfr1; NPFR1; RE18294p
    Summary
    Enables neuropeptide F receptor activity and neuropeptide binding activity. Involved in several processes, including larval feeding behavior; neuropeptide signaling pathway; and response to odorant. Located in plasma membrane. Is expressed in several structures, including crop; embryonic central brain; ganglia; gut section; and larval midline neurons. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in lipid metabolism disorder and obesity. Orthologous to human NPY5R (neuropeptide Y receptor Y5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See NPFR in Genome Data Viewer
    Location:
    83D5-83E1; 3-47.5 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6187315..6195403)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2013037..2021125)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Osiris 1 Neighboring gene pseudo Neighboring gene Osiris 24 Neighboring gene Osiris 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dissection of the Drosophila neuropeptide F circuit using a high-throughput two-choice assay. Shao L, et al. Proc Natl Acad Sci U S A, 2017 Sep 19. PMID 28874527, Free PMC Article
    2. Developmental Ethanol Exposure Causes Reduced Feeding and Reveals a Critical Role for Neuropeptide F in Survival. Guevara A, et al. Front Physiol, 2018. PMID 29623043, Free PMC Article
    3. Graded encoding of food odor value in the Drosophila brain. Beshel J, et al. J Neurosci, 2013 Oct 2. PMID 24089477, Free PMC Article
    4. Neuropeptide F regulates feeding via the juvenile hormone pathway in Ostrinia furnacalis larvae. Yu Z, et al. Pest Manag Sci, 2023 Mar. PMID 36396604
    5. Regulation of sleep by neuropeptide Y-like system in Drosophila melanogaster. He C, et al. PLoS One, 2013. PMID 24040211, Free PMC Article

    See all (143) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A New Role for Neuropeptide F Signaling in Controlling Developmental Timing and Body Size in Drosophila melanogaster.
      Title: A New Role for Neuropeptide F Signaling in Controlling Developmental Timing and Body Size in Drosophila melanogaster.
    2. Male-specific sex-dependent regulatory function of sleep is controlled by NPF and NPFR1 expression in the brain.
      Title: Regulation of sleep by neuropeptide Y-like system in Drosophila melanogaster.
    3. Distribution of short neuropeptide F and its receptor in neuronal circuits related to feeding in larval Drosophila.
      Title: Distribution of short neuropeptide F and its receptor in neuronal circuits related to feeding in larval Drosophila.
    4. in males, mating increased, whereas sexual deprivation reduced, NPF levels; propose that activity of the NPF-NPF receptor axis represents the state of the fly reward system and modifies behavior accordingly
      Title: Sexual deprivation increases ethanol intake in Drosophila.
    5. Expression of sNPF and its receptor (sNPFR1) in Or42b neurons is necessary for starvation-induced food-search behavior.
      Title: Presynaptic facilitation by neuropeptide signaling mediates odor-driven food search.
    6. NPFR requires an Arg residue at position 4 from the amidated C-terminus for ativation by short NPFs
      Title: Characterization of the short neuropeptide F receptor from Drosophila melanogaster.
    7. expressed in CNS and midgut; a functional receptor for Drosophila neuropeptide F (DmNPF)
      Title: Characterization of a functional neuropeptide F receptor from Drosophila melanogaster.
    8. Results identify a Drosophila signaling system, comprising neurons expressing neuropeptide F and its receptor, NPFR1, that acutely mediates sensitivity to ethanol sedation.
      Title: Drosophila neuropeptide F and its receptor, NPFR1, define a signaling pathway that acutely modulates alcohol sensitivity.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables neuropeptide F receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables neuropeptide Y receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in larval feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multi-organism reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in olfactory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to odorant IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tachykinin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuropeptide F receptor
    Names
    CG1147-PA
    CG1147-PB
    CG1147-PC
    CG1147-PD
    NPF-receptor
    NPFR-PA
    NPFR-PB
    NPFR-PC
    NPFR-PD
    dNPF receptor
    neuropeptide F receptor 1
    neuropeptide F receptor-1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      6187315..6195403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079521.4 → NP_524245.3  neuropeptide F receptor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524245.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D2CFP0, D2CFP1, D2CFP2, D2CFP3, D2CFP4, Q7KFF8, Q8SZ35, Q967T7, Q9VNM1
      Related
      FBpp0078239
      Conserved Domains (2) summary
      pfam00001
      Location:103 → 373
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:98 → 195
      7tm_4; Olfactory receptor

    2. NM_001260018.2 → NP_001246947.1  neuropeptide F receptor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246947.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K601
      Conserved Domains (2) summary
      pfam00001
      Location:103 → 373
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:98 → 195
      7tm_4; Olfactory receptor

    3. NM_001260017.2 → NP_001246946.1  neuropeptide F receptor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246946.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6K3
      Conserved Domains (2) summary
      pfam00001
      Location:103 → 373
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:98 → 195
      7tm_4; Olfactory receptor

    4. NM_001260016.2 → NP_001246945.1  neuropeptide F receptor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246945.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6A5
      Conserved Domains (2) summary
      pfam00001
      Location:103 → 373
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:98 → 195
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K601 A0A0B4K601
    A0A0B4K6A5 A0A0B4K6A5
    A0A0B4K6K3 A0A0B4K6K3
    Q9VNM1.3 Q9VNM1

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