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    Ctns Cystinosin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42723, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ctnsprovided by FlyBase
    Official Full Name
    Cystinosinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039045
    Locus tag
    Dmel_CG17119
    See related
    AllianceGenome:FB:FBgn0039045
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17119; CTNS; dCTNS; Dmel\CG17119
    Summary
    Predicted to enable L-cystine transmembrane transporter activity. Predicted to be involved in L-cystine transport and amino acid transmembrane transport. Predicted to be active in lysosomal membrane. Is expressed in several structures, including anterior-posterior subdivision of organism; embryonic central brain neurons; embryonic head sensory system; embryonic hindgut; and embryonic precursor of adult hindgut. Human ortholog(s) of this gene implicated in cystinosis. Orthologous to human CTNS (cystinosin, lysosomal cystine transporter). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ctns in Genome Data Viewer
    Location:
    94D10-94D10; 3-77 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23054410..23058958, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18880132..18884680, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46089 Neighboring gene p53 Neighboring gene Gustatory receptor 94a Neighboring gene salvador Neighboring gene Ubiquitin-like domain-containing C-terminal domain phosphatase 1 Neighboring gene uncharacterized protein Neighboring gene Carrier of Wingless Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Case studies of ends-out gene targeting in Drosophila. Chen H, et al. Genesis, 2009 May. PMID 19298016
    2. In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in Drosophila. Lee JH, et al. FEBS Lett, 2003 Aug 28. PMID 12935877
    3. Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting. Jouandin P, et al. Science, 2022 Feb 18. PMID 35175796, Free PMC Article
    4. Differential amino acid transporter expression in adult Drosophila melanogaster tissues. Wright Y, et al. MicroPubl Biol, 2024. PMID 38481556, Free PMC Article
    5. Genome-wide RNAi screen identifies broadly-acting host factors that inhibit arbovirus infection. Yasunaga A, et al. PLoS Pathog, 2014 Feb. PMID 24550726, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-cystine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-cystine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables L-cystine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-cystine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-cystine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in amino acid transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cystinosin
    Names
    CG17119-PA
    CG17119-PC
    Ctns-PA
    Ctns-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23054410..23058958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176543.2 → NP_788720.2  cystinosin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788720.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7YZ90, Q8MS51, Q9VCR7
      Conserved Domains (2) summary
      TIGR00951
      Location:129 → 362
      2A43; Lysosomal Cystine Transporter
      pfam04193
      Location:132 → 187
      PQ-loop; PQ loop repeat

    2. NM_142859.3 → NP_651116.1  cystinosin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651116.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7YZ90, Q8MS51, Q9VCR7
      Related
      FBpp0083750
      Conserved Domains (2) summary
      TIGR00951
      Location:129 → 362
      2A43; Lysosomal Cystine Transporter
      pfam04193
      Location:132 → 187
      PQ-loop; PQ loop repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7YZ90 Q7YZ90
    Q9VCR7.2 Q9VCR7

    Gene LinkOut

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