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    spg sponge [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43404, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spgprovided by FlyBase
    Official Full Name
    spongeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264324
    Locus tag
    Dmel_CG31048
    See related
    AllianceGenome:FB:FBgn0264324
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11754; CG14530; CG31048; Dm Dock4; Dmel\CG31048; mat(3)6; mat3(6); Spg; Sponge
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in nervous system development and positive regulation of signal transduction. Located in cytosol and plasma membrane. Is expressed in several structures, including adult head; ganglia; muscle cell; presumptive embryonic/larval system; and tract. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to several human genes including DOCK4 (dedicator of cytokinesis 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See spg in Genome Data Viewer
    Location:
    98E6-98F1; 3-97 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28845270..28870439)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24670992..24696161)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene WASp Neighboring gene APC-like Neighboring gene Innexin 3 Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 17 Neighboring gene Neprilysin-like 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila DOCK family protein Sponge is required for development of the air sac primordium. Morishita K, et al. Exp Cell Res, 2017 May 15. PMID 28341448
    2. Morphogenesis in the embryo ofDrosophila melanogaster -germ band extension in the maternal-effect lethalmat(3)6. Rickoll WL, et al. Wilehm Roux Arch Dev Biol, 1981 Sep. PMID 28305343
    3. Maternal effect mutations of the sponge locus affect actin cytoskeletal rearrangements in Drosophila melanogaster embryos. Postner MA, et al. J Cell Biol, 1992 Dec. PMID 1447298, Free PMC Article
    4. Localized defects of blastoderm formation in maternal effect mutants of Drosophila. Rice TB, et al. Dev Biol, 1975 Apr. PMID 805069
    5. Drosophila DOCK family protein sponge regulates the JNK pathway during thorax development. Morishita K, et al. Cell Struct Funct, 2014. PMID 25311449

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The complex ELMO-Sponge is subapically enriched and is required for subapical restriction of Canoe in early embryos. The localization dynamics of ELMO-Sponge suggests a patterning mechanism for positioning the subapical region adjacent to the apical region.
      Title: ELMO and Sponge specify subapical restriction of Canoe and formation of the subapical domain in early Drosophila embryos.
    2. Spg plays a critical role in air sac primordium development.
      Title: The Drosophila DOCK family protein Sponge is required for development of the air sac primordium.
    3. Spg positively regulates JNK pathway that is required for thorax development and the regulation is mediated by interaction with Rac1.
      Title: Drosophila DOCK family protein sponge regulates the JNK pathway during thorax development.
    4. Knockdown of spg reduced the level of activated ERK signal and induces abnormal eye morphology.
      Title: The Drosophila DOCK family protein sponge is involved in differentiation of R7 photoreceptor cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in R7 cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of sevenless signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sponge
    Names
    CG31048-PD
    CG31048-PE
    CG31048-PF
    CG31048-PG
    CG31048-PH
    Dock4
    early-D
    spg-PD
    spg-PE
    spg-PF
    spg-PG
    spg-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      28845270..28870439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144646.2 → NP_001138118.2  sponge, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138118.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0R2
      Conserved Domains (4) summary
      cd08695
      Location:414 → 600
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11696
      Location:1215 → 1610
      DHR2_DOCK_B; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis proteins
      cd11872
      Location:9 → 64
      SH3_DOCK_AB; Src Homology 3 domain of Class A and B Dedicator of Cytokinesis proteins
      pfam16172
      Location:67 → 406
      DOCK_N; DOCK N-terminus

    2. NM_001276120.1 → NP_001263049.1  sponge, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263049.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0R2
      Conserved Domains (4) summary
      cd08695
      Location:414 → 600
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11696
      Location:1215 → 1610
      DHR2_DOCK_B; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis proteins
      cd11872
      Location:9 → 64
      SH3_DOCK_AB; Src Homology 3 domain of Class A and B Dedicator of Cytokinesis proteins
      pfam16172
      Location:67 → 406
      DOCK_N; DOCK N-terminus

    3. NM_170379.5 → NP_733258.4  sponge, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733258.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAS8
      Conserved Domains (4) summary
      cd08695
      Location:414 → 600
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11872
      Location:9 → 64
      SH3_DOCK_AB; Src Homology 3 domain of Class A and B Dedicator of Cytokinesis proteins
      pfam16172
      Location:67 → 406
      DOCK_N; DOCK N-terminus
      cl06123
      Location:1215 → 1610
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    4. NM_001276119.1 → NP_001263048.1  sponge, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263048.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHD2
      Conserved Domains (4) summary
      cd08695
      Location:414 → 600
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11696
      Location:1221 → 1616
      DHR2_DOCK_B; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis proteins
      cd11872
      Location:9 → 64
      SH3_DOCK_AB; Src Homology 3 domain of Class A and B Dedicator of Cytokinesis proteins
      pfam16172
      Location:67 → 406
      DOCK_N; DOCK N-terminus

    5. NM_001276118.1 → NP_001263047.1  sponge, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263047.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHD2
      Conserved Domains (4) summary
      cd08695
      Location:414 → 600
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11696
      Location:1221 → 1616
      DHR2_DOCK_B; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis proteins
      cd11872
      Location:9 → 64
      SH3_DOCK_AB; Src Homology 3 domain of Class A and B Dedicator of Cytokinesis proteins
      pfam16172
      Location:67 → 406
      DOCK_N; DOCK N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHD2 A0A0B4KHD2
    B7Z0R2 B7Z0R2
    Q9VAS8 Q9VAS8

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