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    mesh mesh [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43688, updated on 9-Dec-2024

    Summary

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    Official Symbol
    meshprovided by FlyBase
    Official Full Name
    meshprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051004
    Locus tag
    Dmel_CG31004
    See related
    AllianceGenome:FB:FBgn0051004
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.233; CG12074; CG15560; CG31004; CT5150; Dmel\CG31004; DmMesh; Mesh
    Summary
    Involved in smooth septate junction assembly. Located in apicolateral plasma membrane and smooth septate junction. Is expressed in Malpighian tubule; adult head; and gut section. Orthologous to human SUSD2 (sushi domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mesh in Genome Data Viewer
    Location:
    100B5-100B5; 3-102 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31178389..31195762, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27004111..27021484, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43458 Neighboring gene Guanylyl cyclase beta-subunit at 100B Neighboring gene slow termination of phototransduction Neighboring gene bottleneck Neighboring gene uncharacterized protein Neighboring gene chaoptin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Septate junctions regulate gut homeostasis through regulation of stem cell proliferation and enterocyte behavior in Drosophila. Izumi Y, et al. J Cell Sci, 2019 Sep 26. PMID 31444286
    2. The septate junction protein Tetraspanin 2A is critical to the structure and function of Malpighian tubules in Drosophila melanogaster. Beyenbach KW, et al. Am J Physiol Cell Physiol, 2020 Jun 1. PMID 32267718, Free PMC Article
    3. Thermal acclimation mitigates cold-induced paracellular leak from the Drosophila gut. MacMillan HA, et al. Sci Rep, 2017 Aug 18. PMID 28821771, Free PMC Article
    4. The novel membrane protein Hoka regulates septate junction organization and stem cell homeostasis in the Drosophila gut. Izumi Y, et al. J Cell Sci, 2021 Mar 26. PMID 33589496
    5. The Wnt Co-Receptor PTK7/Otk and Its Homolog Otk-2 in Neurogenesis and Patterning. Tan QH, et al. Cells, 2024 Feb 20. PMID 38474329, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila.
      Title: The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila.
    2. Mesh has a role in the developmental maturation of the Drosophila Malpighian tubule and in ion transport in the adult tubule.
      Title: The septate junction protein Mesh is required for epithelial morphogenesis, ion transport, and paracellular permeability in the Drosophila Malpighian tubule.
    3. Together with Tsp2A, Ssk and Mesh form a protein complex, and all three proteins are required for smooth septate junctions (sSJs) formation, as well as intestinal barrier function.
      Title: Molecular dissection of smooth septate junctions: understanding their roles in arthropod physiology.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in smooth septate junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apicolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in smooth septate junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mesh
    Names
    CG31004-PA
    CG31004-PB
    CG31004-PC
    CG31004-PD
    CG31004-PE
    mesh-PA
    mesh-PB
    mesh-PC
    mesh-PD
    mesh-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31178389..31195762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170310.1 → NP_001163781.1  mesh, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163781.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHZ4
      Conserved Domains (5) summary
      smart00032
      Location:1121 → 1171
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      smart00216
      Location:811 → 999
      VWD; von Willebrand factor (vWF) type D domain
      smart00539
      Location:259 → 419
      NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
      pfam01833
      Location:446 → 511
      TIG; IPT/TIG domain
      pfam03782
      Location:660 → 805
      AMOP; AMOP domain

    2. NM_001300689.1 → NP_001287618.1  mesh, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287618.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHZ4
      Conserved Domains (5) summary
      smart00032
      Location:1121 → 1171
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      smart00216
      Location:811 → 999
      VWD; von Willebrand factor (vWF) type D domain
      smart00539
      Location:259 → 419
      NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
      pfam01833
      Location:446 → 511
      TIG; IPT/TIG domain
      pfam03782
      Location:660 → 805
      AMOP; AMOP domain

    3. NM_170540.1 → NP_733419.1  mesh, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733419.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KHY3
      Related
      FBpp0085141, FBtr0085780
      Conserved Domains (4) summary
      smart00032
      Location:1121 → 1171
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      smart00216
      Location:811 → 999
      VWD; von Willebrand factor (vWF) type D domain
      smart00539
      Location:259 → 419
      NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
      pfam03782
      Location:660 → 805
      AMOP; AMOP domain

    4. NM_170539.1 → NP_733418.1  mesh, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733418.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KHY3
      Related
      FBpp0085140, FBtr0085779
      Conserved Domains (4) summary
      smart00032
      Location:1121 → 1171
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      smart00216
      Location:811 → 999
      VWD; von Willebrand factor (vWF) type D domain
      smart00539
      Location:259 → 419
      NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
      pfam03782
      Location:660 → 805
      AMOP; AMOP domain

    5. NM_001170311.1 → NP_001163782.1  mesh, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163782.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3DNA3, E1JJ26, E1JJ27, E2QD49, Q0KHY3, Q6NND0, Q8MR59
      Conserved Domains (4) summary
      smart00032
      Location:1121 → 1171
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      smart00216
      Location:811 → 999
      VWD; von Willebrand factor (vWF) type D domain
      smart00539
      Location:259 → 419
      NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
      pfam03782
      Location:660 → 805
      AMOP; AMOP domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHZ4 A0A0B4LHZ4
    Q0KHY3.2 Q0KHY3

    Gene LinkOut

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