PGRP-LE Peptidoglycan recognition protein LE [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PGRP-LEprovided by FlyBase
Official Full Name: Peptidoglycan recognition protein LEprovided by FlyBase
Primary source: FLYBASE:FBgn0030695
Locus tag: Dmel_CG8995
See related: AllianceGenome:FB:FBgn0030695
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0153538.66; CG8995; Dmel\CG8995; PGRP; pgrp le; pgrp-le
Summary: Predicted to enable peptidoglycan binding activity. Involved in defense response to other organism; determination of adult lifespan; and positive regulation of phagocytosis. Located in cytosol and extracellular region. Is expressed in adult head; embryonic/larval midgut; and organism. Used to study lower respiratory tract disease. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 13F1-13F1; 1-52 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (15801153..15803880, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (15695186..15697913, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that the absence of functional PGRP-LE alters the transcriptional pathway activity of Imd and Jnk signaling upon infection with Photorhabdus asymbiotica, while infection with Photorhabdus luminescens modifies the activity of Jak/Stat signaling. These findings denote the participation of the PGRP-LE receptor in the response of Drosophila melanogaster to Photorhabdus challenge.
Title: The peptidoglycan recognition protein PGRP-LE regulates the Drosophila immune response against the pathogen Photorhabdus.
Protofibrils of peptidoglycan receptors PGRP-LC and PGRP-LE seed immune deficiency protein (Imd) amyloid polymerization via Imd RIP homotypic interaction motif (RHIM), and the formation of functional Imd amyloid fibril is required for NF-kappaB signaling.
Title: Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling.
PGRP-LE functions as a gut bacterial sensor that induces balanced responses to infectious bacteria and tolerance to microbiota.
Title: Peptidoglycan sensing by the receptor PGRP-LE in the Drosophila gut induces immune responses to infectious bacteria and tolerance to microbiota.
our study delineates how a combination of extracellular sensing by PGRP-LC isoforms and intracellular sensing through PGRP-LE provides sophisticated mechanisms to detect and differentiate between infections in Drosophila.
Title: Tissue- and ligand-specific sensing of gram-negative infection in drosophila by PGRP-LC isoforms and PGRP-LE.
PGRP-LE and PGRP-LC play a crucial role in detecting extracellular and intracellular bacteria with DAP-type peptidoglycans to induce various innate immune responses
Title: Extracellular and intracellular pathogen recognition by Drosophila PGRP-LE and PGRP-LC.
Listericin gene encodes a novel antibacterial peptide-like protein whose induction is cooperatively regulated by PGRP-LE and the JAK-STAT pathway.
Title: Cooperative regulation of the induction of the novel antibacterial Listericin by peptidoglycan recognition protein LE and the JAK-STAT pathway.
The function of PGRP-LE in innate immunity as a recognition receptor for intracellular bacteria was studied.
Title: Induction of autophagy via innate bacterial recognition.
PGRP-LE acts both upstream and in parallel with PGRP-LC in the imd pathway, and is required for infection-dependent activation of melanization in Drosophila.
Title: Peptidoglycan recognition protein (PGRP)-LE and PGRP-LC act synergistically in Drosophila immunity.
PGRP-LE acts as a pattern-recognition receptor to the diaminopimelic acid-type peptidoglycan and activates both the proteolytic cascade and intracellular signaling in immunity.
Title: Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae.
Full-length PGRP-LE acts as an intracellular receptor for monomeric peptidoglycan. A form of PGRP-LE with only the PGRP domain functions extracellularly to enhance PGRP-LC-mediated peptidoglycan recognition on the cell surface.
Title: PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
NOT enables N-acetylmuramoyl-L-alanine amidase activity	IKR Inferred from Key Residues more info	PubMed
enables peptidoglycan binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables peptidoglycan binding	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	NAS Non-traceable Author Statement more info	PubMed
NOT involved_in peptidoglycan catabolic process	IKR Inferred from Key Residues more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagocytosis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: peptidoglycan recognition protein LE

Names: CG8995-PA; CG8995-PB; PGRP-LE-PA; PGRP-LE-PB; peptidoglycan recognition protein; peptidoglycan recognition protein-LE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

15801153..15803880 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001258766.3 → NP_001245695.1 peptidoglycan recognition protein LE, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245695.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VXN9

UniProtKB/TrEMBL

M9NDY2

Conserved Domains (1) summary

smart00701
Location:175 → 317

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
NM_132850.4 → NP_573078.1 peptidoglycan recognition protein LE, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_573078.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VXN9

UniProtKB/TrEMBL

M9NDY2

Related

FBpp0073968

Conserved Domains (1) summary

smart00701
Location:175 → 317

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme