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    tx taxi [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43190, updated on 9-Dec-2024

    Summary

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    Official Symbol
    txprovided by FlyBase
    Official Full Name
    taxiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0288888
    Locus tag
    Dmel_CG5441
    See related
    AllianceGenome:FB:FBgn0288888
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bHLHc10; CG5441; dei; Dei; del; delilah; Delilah; Dmel\CG5441; ju
    Summary
    Enables bHLH transcription factor binding activity. Contributes to E-box binding activity. Involved in cell adhesion mediated by integrin; imaginal disc-derived wing vein specification; and mesoderm development. Located in nucleus. Is expressed in several structures, including anterior wing margin; embryonic dorsal apodeme; embryonic ventral apodeme; larval muscle cell; and visceral muscle primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    97B2-97B2; 3-91 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26440778..26448991)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22266500..22274713)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR31084 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43434 Neighboring gene Hexokinase testis 1 Neighboring gene Hexokinase testis 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Visualization of proprioceptors in Drosophila larvae and pupae. Halachmi N, et al. J Vis Exp, 2012 Jun 13. PMID 22733157, Free PMC Article
    2. Neuronal role of taxi is imperative for flight in Drosophila melanogaster. Varte V, et al. Gene, 2022 Jul 30. PMID 35597528
    3. On neurogenetic relations in Drosophila melanogaster. Chiarodo A, et al. J Exp Zool, 1971 Nov. PMID 4255937
    4. A temperature-sensitive brain tumor suppressor mutation of Drosophila melanogaster: developmental studies and molecular localization of the gene. Gateff E, et al. Mech Dev, 1993 Apr. PMID 8507589
    5. A component of calcium-activated potassium channels encoded by the Drosophila slo locus. Atkinson NS, et al. Science, 1991 Aug 2. PMID 1857984

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study shows that activation of dei transcription is mediated through multiple cis regulatory modules, each driving transcription in a spatially and temporally restricted fashion.
      Title: Deconstructing the complexity of regulating common properties in different cell types: lessons from the delilah gene.
    2. Spatial regulation of cell adhesion in the Drosophila wing is mediated by Delilah, a potent activator of betaPS integrin expression.
      Title: Spatial regulation of cell adhesion in the Drosophila wing is mediated by Delilah, a potent activator of βPS integrin expression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IC
    Inferred by Curator
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    contributes_to E-box binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables bHLH transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion mediated by integrin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing vein specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mesoderm development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in somatic muscle development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    taxi
    Names
    CG5441-PA
    CG5441-PB
    delilah
    jumper
    taxi wings
    tx-PA
    tx-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26440778..26448991
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300614.1 → NP_001287543.1  taxi, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287543.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41894, Q961H7, Q9VBF2
      UniProtKB/TrEMBL
      A0A0B4LIQ1
      Conserved Domains (1) summary
      pfam00010
      Location:95 → 154
      HLH; Helix-loop-helix DNA-binding domain

    2. NM_079792.3 → NP_524516.2  taxi, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524516.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41894, Q961H7, Q9VBF2
      UniProtKB/TrEMBL
      A0A0B4LIQ1
      Related
      FBpp0084381
      Conserved Domains (1) summary
      pfam00010
      Location:95 → 154
      HLH; Helix-loop-helix DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LIQ1 A0A0B4LIQ1
    P41894.3 P41894

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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