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    CG6180 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34683, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG6180provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032453
    Locus tag
    Dmel_CG6180
    See related
    AllianceGenome:FB:FBgn0032453
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6180
    Summary
    Predicted to be involved in negative regulation of ERK1 and ERK2 cascade. Predicted to be located in cytosol and mitochondrion. Is expressed in several structures, including adult head; adult heart; gut section; posterior endoderm; and posterior midgut primordium. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human PEBP1 (phosphatidylethanolamine binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6180 in Genome Data Viewer
    Location:
    33F3-33F3; 2-47 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12707661..12708680)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12707661..12708680)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene spichthyin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene PIH1 domain containing 1 Neighboring gene Multidrug-Resistance like Protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression and characterization of the PEBP homolog genes from Drosophila. Rautureau G, et al. Arch Insect Biochem Physiol, 2009 Jun. PMID 19309003
    2. Juvenile hormone counteracts the bHLH-PAS transcription factors MET and GCE to prevent caspase-dependent programmed cell death in Drosophila. Liu Y, et al. Development, 2009 Jun. PMID 19465595
    3. Genome-wide analysis of the maternal-to-zygotic transition in Drosophila primordial germ cells. Siddiqui NU, et al. Genome Biol, 2012 Feb 20. PMID 22348290, Free PMC Article
    4. The hemolymph proteome of fed and starved Drosophila larvae. Handke B, et al. PLoS One, 2013. PMID 23840627, Free PMC Article
    5. Leishmania amazonensis sabotages host cell SUMOylation for intracellular survival. Okuda K, et al. iScience, 2022 Sep 16. PMID 36060064, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6180-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12707661..12708680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135744.2 → NP_609588.1  uncharacterized protein Dmel_CG6180 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609588.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0L1, Q9VK60
      Related
      FBpp0079979
      Conserved Domains (1) summary
      cd00866
      Location:100 → 242
      PEBP_euk; PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VK60 Q9VK60

    Gene LinkOut

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