yin yin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: yinprovided by FlyBase
Official Full Name: yinprovided by FlyBase
Primary source: FLYBASE:FBgn0265575
Locus tag: Dmel_CG44402
See related: AllianceGenome:FB:FBgn0265575
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2913; CG34336; CG44402; Dmel\CG44402; EG:EG0002.1; opt; opt1; Opt1; OpT1; OPT1; Yin
Old locus tag: Dmel_CG2913; Dmel_CG34336
Summary: Enables oligopeptide transmembrane transporter activity and proton-dependent oligopeptide secondary active transmembrane transporter activity. Involved in dipeptide transmembrane transport. Located in phagocytic vesicle membrane and plasma membrane. Is expressed in several structures, including adult antennal nerve; epithelial tube; female germline cell; ganglia; and gut section. Orthologous to several human genes including SLC15A1 (solute carrier family 15 member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 3F3-3F4; 1-5 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (3862966..3871939, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (3756999..3765972, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results show that Yin is required neither for peptidoglycan recognition protein activation by peptidoglycans nor for peptidoglycan transport from the gut lumen to the insect blood
Title: Oligopeptide Transporters of the SLC15 Family Are Dispensable for Peptidoglycan Sensing and Transport in Drosophila.
Data identify Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated transporters.
Title: Identification of Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables dipeptide transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables oligopeptide transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables oligopeptide transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables proton-dependent oligopeptide secondary active transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in dipeptide import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in dipeptide transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oligopeptide transport	IDA Inferred from Direct Assay more info	PubMed
involved_in oligopeptide transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle membrane	IGI Inferred from Genetic Interaction more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: yin

Names: CG44402-PA; CG44402-PB; CG44402-PC; CG44402-PD; oligopeptide transporter 1; yin-PA; yin-PB; yin-PC; yin-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

3862966..3871939 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001297915.1 → NP_001284844.1 yin, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284844.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JAE6

Conserved Domains (2) summary

TIGR00926
Location:85 → 719

2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)

cl21472
Location:138 → 398

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
NM_057799.4 → NP_477147.2 yin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477147.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A9UNA2, A9UNE6, O77281, O77282, P91679, Q7K7E7, Q7KVX8, Q8IRT2, Q95TX0, Q9TY25, Q9TY26, Q9W4P7, Q9W4P8

Related

FBpp0309179

Conserved Domains (2) summary

TIGR00926
Location:48 → 682

2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)

cl21472
Location:101 → 361

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
NM_166993.2 → NP_726894.1 yin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726894.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P91679

Related

FBpp0309181

Conserved Domains (2) summary

TIGR00926
Location:39 → 673

2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)

cl21472
Location:92 → 352

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
NM_057800.4 → NP_477148.2 yin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477148.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P91679

Related

FBpp0309180

Conserved Domains (2) summary

TIGR00926
Location:42 → 676

2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)

cl21472
Location:95 → 355

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...