Egm Enigma [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Egmprovided by FlyBase
Official Full Name: Enigmaprovided by FlyBase
Primary source: FLYBASE:FBgn0086712
Locus tag: Dmel_CG9006
See related: AllianceGenome:FB:FBgn0086712
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Acyl CoA DH; CG9006; dACAD9; Dmel\CG9006; egm; l(2)k14708
Summary: Predicted to enable medium-chain fatty acyl-CoA dehydrogenase activity. Involved in several processes, including compound eye morphogenesis; fatty acid beta-oxidation; and negative regulation of cellular response to oxidative stress. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gut section; and mesoderm. Used to study nuclear type mitochondrial complex I deficiency 20. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 20. Orthologous to human ACAD9 (acyl-CoA dehydrogenase family member 9) and ACADL (acyl-CoA dehydrogenase long chain). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (11616869..11619023, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (7504374..7506528, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables medium-chain fatty acyl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in compound eye morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fatty acid beta-oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in medium-chain fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to endoplasmic reticulum stress	HMP more info	PubMed
involved_in sexual reproduction	HEP more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

NP_610687.1

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The following sections contain reference sequences that belong to a specific genome build. Explain