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    Nek2 Nek2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31696, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nek2provided by FlyBase
    Official Full Name
    Nek2provided by FlyBase
    Primary source
    FLYBASE:FBgn0029970
    Locus tag
    Dmel_CG17256
    See related
    AllianceGenome:FB:FBgn0029970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17256; Dm Nek2; Dmel\CG17256; DmNek2; dNek2; NEK2
    Summary
    Enables protein serine/threonine kinase activity. Involved in compound eye photoreceptor cell differentiation; positive regulation of canonical Wnt signaling pathway; and regulation of mitotic nuclear division. Located in centrosome and midbody. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; endoderm anlage; head epidermis primordium; and mesoderm. Used to study cancer. Human ortholog(s) of this gene implicated in retinitis pigmentosa 67. Orthologous to human NEK2 (NIMA related kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Nek2 in Genome Data Viewer
    Location:
    7C1-7C1; 1-21 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7889066..7891646, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7783099..7785679, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 7g Neighboring gene Acetyl-CoA acetyltransferase 1 Neighboring gene NADH dehydrogenase (ubiquinone) MNLL subunit Neighboring gene uncharacterized protein Neighboring gene p115

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation and functions of inhibitor-2 family of proteins. Li M, et al. Biochemistry, 2007 Mar 6. PMID 17286390
    2. Caught Nek-ing: cilia and centrioles. Quarmby LM, et al. J Cell Sci, 2005 Nov 15. PMID 16280549
    3. Proper recruitment of gamma-tubulin and D-TACC/Msps to embryonic Drosophila centrosomes requires Centrosomin Motif 1. Zhang J, et al. Mol Biol Cell, 2007 Oct. PMID 17671162, Free PMC Article
    4. Cross species systems biology discovers glial DDR2, STOM, and KANK2 as therapeutic targets in progressive supranuclear palsy. Min Y, et al. Nat Commun, 2023 Nov 2. PMID 37919278, Free PMC Article
    5. Drosophila Nek2 protein kinase knockdown leads to centrosome maturation defects while overexpression causes centrosome fragmentation and cytokinesis failure. Prigent C, et al. Exp Cell Res, 2005 Feb 1. PMID 15572022

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. APC/C(Fzr/Cdh1) negatively regulates Nek2, which negatively regulates Dsh, to ensure its proper stoichiometric requirement and localization during planar cell polarity establishment.
      Title: APC/C(Fzr/Cdh1)-Dependent Regulation of Planar Cell Polarity Establishment via Nek2 Kinase Acting on Dishevelled.
    2. The APC/C degrades dNek2 upon synchronous G1 arrest prior to differentiation, which allows retinal differentiation through local suppression of Wg signaling.
      Title: The APC/C Coordinates Retinal Differentiation with G1 Arrest through the Nek2-Dependent Modulation of Wingless Signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in compound eye photoreceptor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Nek2
    Names
    CG17256-PA
    Nek2-PA
    NP_572415.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7889066..7891646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132187.3 → NP_572415.1  Nek2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572415.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3N8
      Related
      FBpp0071094
      Conserved Domains (2) summary
      smart00220
      Location:19 → 281
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08217
      Location:18 → 281
      STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3N8 Q9W3N8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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