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    pie pineapple eye [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44315, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pieprovided by FlyBase
    Official Full Name
    pineapple eyeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0005683
    Locus tag
    Dmel_CG5354
    See related
    AllianceGenome:FB:FBgn0005683
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5354; Dmel\CG5354; l(2)31Ek; l(2)54; mat(2)ea-E; mat(2)earlyQM47; mat(2)QM47; Pie
    Summary
    Involved in several processes, including germ-line stem cell division; intestinal stem cell homeostasis; and somatic stem cell population maintenance. Predicted to be active in nucleus. Is expressed in organism. Orthologous to several human genes including PHF7 (PHD finger protein 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pie in Genome Data Viewer
    Location:
    31E1-31E1; 2-42 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10420625..10422780, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10420625..10422780, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Kinesin-like protein at 31E Neighboring gene Replication factor C subunit 3 Neighboring gene WD repeat and FYVE domain containing 2 Neighboring gene Small ribonucleoprotein particle protein SmB

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss-of-Function Screen Reveals Novel Regulators Required for Drosophila Germline Stem Cell Self-Renewal. Xing Y, et al. G3 (Bethesda), 2012 Mar. PMID 22413088, Free PMC Article
    2. Evidence for parallel evolution of a gene involved in the regulation of spermatogenesis. Wang XR, et al. Proc Biol Sci, 2017 May 31. PMID 28539513, Free PMC Article
    3. Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila. Mlodzik M, et al. Genes Dev, 1990 Nov. PMID 2125959
    4. Local Cell Death Changes the Orientation of Cell Division in the Developing Drosophila Wing Imaginal Disc Without Using Fat or Dachsous as Orienting Signals. Kale A, et al. PLoS One, 2016. PMID 28030539, Free PMC Article
    5. The pineapple eye gene is required for survival of Drosophila imaginal disc cells. Shi W, et al. Genetics, 2003 Dec. PMID 14704172, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ-line stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intestinal stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pineapple eye
    Names
    CG5354-PA
    CG5354-PB
    lethal(2)54
    maternal effect early arrest E
    pie-PA
    pie-PB
    rumpled

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10420625..10422780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273419.1 → NP_001260348.1  pineapple eye, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260348.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NGN6, Q9VKW2
      Conserved Domains (2) summary
      pfam17061
      Location:318 → 491
      PARM; PARM
      cl22851
      Location:9 → 117
      PHD_SF; PHD finger superfamily

    2. NM_080001.4 → NP_524740.2  pineapple eye, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524740.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NGN6, Q9VKW2
      Related
      FBpp0079636
      Conserved Domains (2) summary
      pfam17061
      Location:318 → 491
      PARM; PARM
      cl22851
      Location:9 → 117
      PHD_SF; PHD finger superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKW2.1 Q9VKW2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
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