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    Pbp95 PSEA-binding protein 95kD [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40949, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pbp95provided by FlyBase
    Official Full Name
    PSEA-binding protein 95kDprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037540
    Locus tag
    Dmel_CG2702
    See related
    AllianceGenome:FB:FBgn0037540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.359; BEST:LD28511; CG2702; Dmel\CG2702; DmPBP; DmPBP95; DmSNAP190; DmSNAPc
    Summary
    Enables RNA polymerase III type 3 promoter sequence-specific DNA binding activity and bent DNA binding activity. Contributes to RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in protein-DNA complex assembly; snRNA transcription by RNA polymerase II; and snRNA transcription by RNA polymerase III. Part of snRNA-activating protein complex. Is expressed in organism. Orthologous to human SNAPC4 (small nuclear RNA activating complex polypeptide 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pbp95 in Genome Data Viewer
    Location:
    84E8-84E8; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8013791..8016610)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3839513..3842332)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ecdysone-inducible gene E3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a Drosophila proximal-sequence-element-binding protein involved in transcription of small nuclear RNA genes. Su Y, et al. Eur J Biochem, 1997 Aug 15. PMID 9310383
    2. Similarities and differences in the conformation of protein-DNA complexes at the U1 and U6 snRNA gene promoters. Hardin SB, et al. Nucleic Acids Res, 2000 Jul 15. PMID 10908334, Free PMC Article
    3. A map of Drosophila melanogaster small nuclear RNA-activating protein complex (DmSNAPc) domains involved in subunit assembly and DNA binding. Hung KH, et al. J Biol Chem, 2009 Aug 21. PMID 19556241, Free PMC Article
    4. Regulation of snRNA gene expression by the Drosophila melanogaster small nuclear RNA activating protein complex (DmSNAPc). Hung KH, et al. Crit Rev Biochem Mol Biol, 2011 Feb. PMID 20925482
    5. Localization of residues in a novel DNA-binding domain of DmSNAP43 required for DmSNAPc DNA-binding activity. Hung KH, et al. FEBS Lett, 2012 Mar 23. PMID 22449969

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results of the study are consistent with a model in which the specific DNA sequences of the U1 and U6 Promoter differentially alter the conformation of DmSNAPc, leading to the subsequent recruitment of different RNA polymerases to the U1 and U6 gene promoters.
      Title: The Myb domain of the largest subunit of SNAPc adopts different architectural configurations on U1 and U6 snRNA gene promoter sequences.
    2. The results reveal the topological arrangement of the 4.5 SNAP190 Myb repeats relative to the DNA and to each other when SNAP190 is bound to a U1 promoter as a subunit of SNAPc.
      Title: Architectural arrangement of the small nuclear RNA (snRNA)-activating protein complex 190 subunit (SNAP190) on U1 snRNA gene promoter DNA.
    3. The results indicated that the C-terminal domain of DmSNAP190 is essential for DmSNAPc to bind efficiently to the PSEA, even though it is not required for assembly with either DmSNAP43 or DmSNAP50 .
      Title: A map of Drosophila melanogaster small nuclear RNA-activating protein complex (DmSNAPc) domains involved in subunit assembly and DNA binding.
    4. Results support a model in which conformational differences in proximal sequence element binding protein (DmPBP)-DNA complexes lead to selective RNA polymerase recruitment to U1 and U6 promoters.
      Title: Architectural arrangement of cloned proximal sequence element-binding protein subunits on Drosophila U1 and U6 snRNA gene promoters.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase III type 3 promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase III type 3 promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables bent DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein-DNA complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in snRNA transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA transcription by RNA polymerase II IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in snRNA transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in snRNA transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of snRNA-activating protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of snRNA-activating protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of snRNA-activating protein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PSEA-binding protein 95kD
    Names
    CG2702-PA
    PSEA-binding protein
    Pbp95-PA
    drosophila melanogaster PSE-binding protein 95-kDa subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8013791..8016610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141503.4 → NP_649760.1  PSEA-binding protein 95kD [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649760.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHX0
      Related
      FBpp0081282
      Conserved Domains (5) summary
      smart00717
      Location:229 → 276
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:229 → 275
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:287 → 350
      Myb_DNA-bind_6; Myb-like DNA-binding domain
      cl01888
      Location:4 → 74
      DUF883; Bacterial protein of unknown function (DUF883)
      cl21498
      Location:194 → 240
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHX0 Q9VHX0

    Gene LinkOut

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