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    Pex16 Peroxin 16 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40293, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pex16provided by FlyBase
    Official Full Name
    Peroxin 16provided by FlyBase
    Primary source
    FLYBASE:FBgn0037019
    Locus tag
    Dmel_CG3947
    See related
    AllianceGenome:FB:FBgn0037019
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3947; DmelPex16; Dmel\CG3947; pex16; PEX16
    Summary
    Involved in peroxisome organization; spermatogenesis; and very long-chain fatty acid catabolic process. Located in peroxisome. Is expressed in adult head and organism. Used to study Zellweger syndrome and peroxisome biogenesis disorder 8A. Human ortholog(s) of this gene implicated in Peroxisome biogenesis disorder 8B and peroxisome biogenesis disorder 8A. Orthologous to human PEX16 (peroxisomal biogenesis factor 16). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pex16 in Genome Data Viewer
    Location:
    77E6-77E6; 3-47 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20776766..20778264, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20769866..20771364, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pitslre Neighboring gene Peroxin 14 Neighboring gene Phosphorylated CTD-interacting factor 1 Neighboring gene antisense RNA:CR46484 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Peroxisomal biogenesis is genetically and biochemically linked to carbohydrate metabolism in Drosophila and mouse. Wangler MF, et al. PLoS Genet, 2017 Jun. PMID 28640802, Free PMC Article
    2. Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes. Nakayama M, et al. PLoS One, 2011. PMID 21826223, Free PMC Article
    3. The role of Peroxin 7 during Drosophila embryonic development. Pridie C, et al. Genome, 2021 Feb. PMID 32191843
    4. Recruitment of Peroxin 14 to lipid droplets affects lipid storage in Drosophila. Ueda K, et al. J Cell Sci, 2022 Apr 1. PMID 35274690
    5. Drosophila models of peroxisomal biogenesis disorder: peroxins are required for spermatogenesis and very-long-chain fatty acid metabolism. Chen H, et al. Hum Mol Genet, 2010 Feb 1. PMID 19933170

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in peroxisome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peroxisome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peroxisome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in protein import into peroxisome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in very long-chain fatty acid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peroxin 16
    Names
    CG3947-PA
    Pex16-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20776766..20778264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140995.4 → NP_649252.1  peroxin 16 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649252.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VPB9
      Related
      FBpp0077936
      Conserved Domains (1) summary
      pfam08610
      Location:11 → 333
      Pex16; Peroxisomal membrane protein (Pex16)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPB9 Q9VPB9

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