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    GAPsec GTPase activating protein, SECIS-dependent read-through [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38987, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GAPsecprovided by FlyBase
    Official Full Name
    GTPase activating protein, SECIS-dependent read-throughprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035916
    Locus tag
    Dmel_CG5978
    See related
    AllianceGenome:FB:FBgn0035916
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD24460; CG5978; dGAPsec; Dmel\CG5978
    Summary
    Enables GTPase binding activity and translation elongation factor binding activity. Involved in translational readthrough. Located in cytoplasm. Orthologous to human TBC1D13 (TBC1 domain family member 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GAPsec in Genome Data Viewer
    Location:
    66D8-66D8; 3-26 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8622039..8623901, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8615139..8617001, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sperm-Leucylaminopeptidase 1 Neighboring gene Sperm-Leucylaminopeptidase 2 Neighboring gene Z band alternatively spliced PDZ-motif protein 66 Neighboring gene Cell division cycle 6 Neighboring gene Cuticular protein 66D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recurrent gene co-amplification on Drosophila X and Y chromosomes. Ellison C, et al. PLoS Genet, 2019 Jul. PMID 31329593, Free PMC Article
    2. A novel stem loop control element-dependent UGA read-through system without translational selenocysteine incorporation in Drosophila. Hirosawa-Takamori M, et al. FASEB J, 2009 Jan. PMID 18772345, Free PMC Article
    3. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins. Gabernet-Castello C, et al. Mol Biol Cell, 2013 May. PMID 23485563, Free PMC Article
    4. Evi5 promotes collective cell migration through its Rab-GAP activity. Laflamme C, et al. J Cell Biol, 2012 Jul 9. PMID 22778279, Free PMC Article
    5. Identification of Cellular Genes Involved in Baculovirus GP64 Trafficking to the Plasma Membrane. Hodgson JJ, et al. J Virol, 2022 Jun 22. PMID 35608346, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation elongation factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in selenocysteine incorporation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translational readthrough IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GTPase activating protein, SECIS-dependent read-through
    Names
    CG5978-PA
    GAPsec-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8622039..8623901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139988.5 → NP_648245.2  GTPase activating protein, SECIS-dependent read-through [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648245.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TT8, Q9VSM8
      Related
      FBpp0076372
      Conserved Domains (1) summary
      smart00164
      Location:191 → 373
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95TT8 Q95TT8
    Q9VSM8 Q9VSM8

    Gene LinkOut

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