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    bisc biscotti [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37443, updated on 9-Dec-2024

    Summary

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    Official Symbol
    biscprovided by FlyBase
    Official Full Name
    biscottiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034626
    Locus tag
    Dmel_CG10795
    See related
    AllianceGenome:FB:FBgn0034626
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10795; Dmel\CG10795; LD27358
    Summary
    Involved in positive regulation of Notch signaling pathway. Predicted to be located in plasma membrane. Is expressed in organism. Used to study Alzheimer's disease. Orthologous to human TM2D1 (TM2 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See bisc in Genome Data Viewer
    Location:
    57E1-57E1; 2-95 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21383227..21384391, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17270732..17271896, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene crossveinless 2 Neighboring gene eukaryotic translation elongation factor, selenocysteine-specific Neighboring gene acyl-Coenzyme A oxidase at 57D proximal

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional unknomics: Systematic screening of conserved genes of unknown function. Rocha JJ, et al. PLoS Biol, 2023 Aug. PMID 37552676, Free PMC Article
    2. Conserved selenoprotein synthesis is not critical for oxidative stress defence and the lifespan of Drosophila. Hirosawa-Takamori M, et al. EMBO Rep, 2004 Mar. PMID 14978508, Free PMC Article
    3. TM2D genes regulate Notch signaling and neuronal function in Drosophila. Salazar JL, et al. PLoS Genet, 2021 Dec. PMID 34905536, Free PMC Article
    4. Crossveinless 2 contains cysteine-rich domains and is required for high levels of BMP-like activity during the formation of the cross veins in Drosophila. Conley CA, et al. Development, 2000 Sep. PMID 10952893
    5. Human Diseases Associated with Notch Signalling: Lessons from Drosophila melanogaster. Megaly M, et al. Front Biosci (Landmark Ed), 2024 Jun 25. PMID 38940046

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TM2D genes regulate Notch signaling and neuronal function in Drosophila.
      Title: TM2D genes regulate Notch signaling and neuronal function in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in positive regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    biscotti
    Names
    CG10795-PA
    CG10795-PB
    bisc-PA
    bisc-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21383227..21384391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001369962.1 → NP_001356967.1  biscotti, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4P7VA98
      Conserved Domains (1) summary
      pfam05154
      Location:94 → 137
      TM2; TM2 domain

    2. NM_137739.3 → NP_611583.1  biscotti, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611583.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W2H1
      Related
      FBpp0071535
      Conserved Domains (1) summary
      pfam05154
      Location:94 → 137
      TM2; TM2 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A4P7VA98 A0A4P7VA98
    Q9W2H1.1 Q9W2H1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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