P32 P32 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: P32provided by FlyBase
Official Full Name: P32provided by FlyBase
Primary source: FLYBASE:FBgn0034259
Locus tag: Dmel_CG6459
See related: AllianceGenome:FB:FBgn0034259
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG 6459; CG6459; Dmel\CG6459; dp32; p32; TAP; TAP/p32
Summary: Enables histone binding activity. Involved in several processes, including neuromuscular synaptic transmission; nucleosome assembly; and sperm DNA decondensation. Located in mitochondrion and nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; gut section; head; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 33. Orthologous to human C1QBP (complement C1q binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (17671309..17672640, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (13558814..13560145, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Genetic and pharmacologic p32-inhibition rescue CHCHD2-linked Parkinson's disease phenotypes in vivo and in cell models.
Title: Genetic and pharmacologic p32-inhibition rescue CHCHD2-linked Parkinson's disease phenotypes in vivo and in cell models.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables C5-methylcytidine-containing RNA reader activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in cytosolic ribosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial RNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleosome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in sperm DNA decondensation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed