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    Kr-h1 Kruppel homolog 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33861, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Kr-h1provided by FlyBase
    Official Full Name
    Kruppel homolog 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0266450
    Locus tag
    Dmel_CG45074
    See related
    AllianceGenome:FB:FBgn0266450
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    44/11; CG18783; CG45074; CG9167; Dmel\CG45074; Kr h; Kr-h; kr-h1; Kr-H1; l(2)05208; l(2)10642; P381; Pow
    Old locus tag
    Dmel_CG18783
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of compound eye photoreceptor development; negative regulation of neuron projection development; and response to ecdysone. Located in cytosol and nucleus. Is expressed in several structures, including CNS glial cell; embryonic/larval midgut primordium; ganglia; gland; and sensory nervous system primordium. Orthologous to human ZBTB48 (zinc finger and BTB domain containing 48). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Kr-h1 in Genome Data Viewer
    Location:
    26B5-26B5; 2-18 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6082603..6096498)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6082603..6096498)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR9162 Neighboring gene long non-coding RNA:CR44773 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene stathmin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamic localisation of KR-H during an ecdysone response in Drosophila. Beck Y, et al. Gene Expr Patterns, 2005 Feb. PMID 15661647
    2. A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segmentation gene. Schuh R, et al. Cell, 1986 Dec 26. PMID 3096579
    3. MicroRNA miR-927 targets the juvenile hormone primary response gene Krüppel homolog1 to control Drosophila developmental growth. He Q, et al. Insect Mol Biol, 2020 Dec. PMID 32715555
    4. Krüppel-homolog is essential for the coordination of regulatory gene hierarchies in early Drosophila development. Beck Y, et al. Dev Biol, 2004 Apr 1. PMID 15031105
    5. Transcription factor E93 specifies adult metamorphosis in hemimetabolous and holometabolous insects. Ureña E, et al. Proc Natl Acad Sci U S A, 2014 May 13. PMID 24778249, Free PMC Article

    See all (128) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Juvenile hormone signal transducer hairy inhibits Kruppel homolog1 expression.
      Title: Juvenile hormone signal transducer hairy inhibits Krüppel homolog1 expression.
    2. Fat body-derived juvenile hormone acid methyltransferase functions to maintain iron homeostasis in Drosophila melanogaster.
      Title: Fat body-derived juvenile hormone acid methyltransferase functions to maintain iron homeostasis in Drosophila melanogaster.
    3. Juvenile hormone inhibits adult cuticle formation in Drosophila melanogaster through Kr-h1/Dnmt2-mediated DNA methylation of Acp65A promoter.
      Title: Juvenile hormone inhibits adult cuticle formation in Drosophila melanogaster through Kr-h1/Dnmt2-mediated DNA methylation of Acp65A promoter.
    4. MicroRNA miR-927 targets the juvenile hormone primary response gene Kruppel homolog1 to control Drosophila developmental growth.
      Title: MicroRNA miR-927 targets the juvenile hormone primary response gene Krüppel homolog1 to control Drosophila developmental growth.
    5. Kr-h1 represses ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes in both Drosophila and Bombyx.
      Title: Krüppel homolog 1 represses insect ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes.
    6. During photoreceptor differentiation, transient repression of Kr-h1 represents a key step regulating neuronal maturation.
      Title: Orthodenticle and Kruppel homolog 1 regulate Drosophila photoreceptor maturation.
    7. KR-H1 has a potential for modulating neuronal morphogenesis, it appears physiologically involved in coordinating general ecdysone signaling.
      Title: Roles of Drosophila Kruppel-homolog 1 in neuronal morphogenesis.
    8. At the chromosomal level, KR-H localisation is dynamic and that the protein is recruited to, and released from, loci harbouring an important subset of the known regulatory genes as the response advances.
      Title: Dynamic localisation of KR-H during an ecdysone response in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in metamorphosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of compound eye photoreceptor development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to ecdysone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kruppel homolog 1
    Names
    CG45074-PA
    CG45074-PB
    Kr-h1-PA
    Kr-h1-PB
    Krueppel-homolog alpha-isoform
    Kruppel-homolog 1
    Kruppel-homolog-1
    krupple homolog 1
    passion of white

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6082603..6096498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058119.5 → NP_477467.1  kruppel homolog 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477467.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P08155
      Related
      FBpp0310809
      Conserved Domains (4) summary
      COG5048
      Location:216 → 366
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:219 → 239
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:387 → 409
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:259 → 284
      zf-H2C2_2; Zinc-finger double domain

    2. NM_058118.5 → NP_477466.1  kruppel homolog 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477466.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P08155, Q9VMH5
      Related
      FBpp0310810
      Conserved Domains (4) summary
      COG5048
      Location:270 → 420
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:273 → 293
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:441 → 463
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:313 → 338
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08155.2 P08155

    Gene LinkOut

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