Inx3 Innexin 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Inx3provided by FlyBase
Official Full Name: Innexin 3provided by FlyBase
Primary source: FLYBASE:FBgn0265274
Locus tag: Dmel_CG1448
See related: AllianceGenome:FB:FBgn0265274
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:fe2B11; CG1448; Dm-inx3; Dm-Inx3; Dmel\CG1448; FBpp0084719; inx-3; INX-3; inx3; Ix3
Summary: Enables gap junction channel activity. Involved in dorsal closure; intercellular transport; and phototransduction, visible light. Located in gap junction and lateral plasma membrane. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; follicle cell; gut section; and head epidermis primordium. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (28853606..28859497, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (24679328..24685219, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Integration of Migratory Cells into a New Site In Vivo Requires Channel-Independent Functions of Innexins on Microtubules.
Title: Integration of Migratory Cells into a New Site In Vivo Requires Channel-Independent Functions of Innexins on Microtubules.
putative Inx2/Inx3 heteromeric channels regulate organ size.
Title: The gap junction protein Innexin3 is required for eye disc growth in Drosophila.
Data propose that Inx3 is a critical factor for dorsal closure and that it mediates the stability of Inx1, 2 and DE-cadherin by forming a complex.
Title: Innexin 3, a new gene required for dorsal closure in Drosophila embryo.
Innexin 3 was observed laterally in follicle cells and also in nurse cells.
Title: Gap junctions in the ovary of Drosophila melanogaster: localization of innexins 1, 2, 3 and 4 and evidence for intercellular communication via innexin-2 containing channels.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables gap junction channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables gap junction channel activity	IC Inferred by Curator more info	PubMed
enables gap junction channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intercellular transport	IDA Inferred from Direct Assay more info	PubMed
involved_in phototransduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phototransduction, visible light	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in gap junction	IBA Inferred from Biological aspect of Ancestor more info
located_in gap junction	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed