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    dgt3 dim gamma-tubulin 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37377, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dgt3provided by FlyBase
    Official Full Name
    dim gamma-tubulin 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0034569
    Locus tag
    Dmel_CG3221
    See related
    AllianceGenome:FB:FBgn0034569
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3221; Dgt3; dim; Dmel\CG3221
    Summary
    Enables protein-macromolecule adaptor activity. Involved in mitotic spindle assembly; mitotic spindle-templated microtubule nucleation; and regulation of mitotic nuclear division. Part of HAUS complex. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dgt3 in Genome Data Viewer
    Location:
    57B5-57B5; 2-92 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20992276..20994381, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16879781..16881886, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Proteasome alpha3 subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. γ-TuRCs and the augmin complex are required for the development of highly branched dendritic arbors in Drosophila. Mukherjee A, et al. J Cell Sci, 2024 May 1. PMID 38606636, Free PMC Article
    2. Wac: a new Augmin subunit required for chromosome alignment but not for acentrosomal microtubule assembly in female meiosis. Meireles AM, et al. J Cell Biol, 2009 Mar 23. PMID 19289792, Free PMC Article
    3. Cross-linking mass spectrometry identifies new interfaces of Augmin required to localise the γ-tubulin ring complex to the mitotic spindle. Chen JWC, et al. Biol Open, 2017 May 15. PMID 28351835, Free PMC Article
    4. Augmin complex activity finetunes dendrite morphology through non-centrosomal microtubule nucleation in vivo. Zhang Y, et al. J Cell Sci, 2024 May 1. PMID 38587100, Free PMC Article
    5. Chromatin-mediated microtubule nucleation in Drosophila syncytial embryos. Hayward D, et al. Commun Integr Biol, 2014. PMID 25053984, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic spindle assembly IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle-templated microtubule nucleation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitotic spindle-templated microtubule nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of HAUS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dim gamma-tubulin 3
    Names
    CG3221-PB
    dgt3-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20992276..20994381 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137689.5 → NP_611533.2  dim gamma-tubulin 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611533.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C9QP53, Q7K3C0, Q9W2P0
      Conserved Domains (1) summary
      pfam14932
      Location:22 → 257
      HAUS-augmin3; HAUS augmin-like complex subunit 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2P0.2 Q9W2P0

    Gene LinkOut

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