RluA-2 RluA pseudouridine synthase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: RluA-2provided by FlyBase
Official Full Name: RluA pseudouridine synthase 2provided by FlyBase
Primary source: FLYBASE:FBgn0032256
Locus tag: Dmel_CG6187
See related: AllianceGenome:FB:FBgn0032256
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6187; Dmel\CG6187; yumo
Summary: Enables pseudouridine synthase activity. Involved in mRNA pseudouridine synthesis. Is expressed in larval dorsal multidendritic neurons and organism. Orthologous to human RPUSD2 (RNA pseudouridine synthase domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 31F1-31F1; 2-43 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10477073..10482975)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10477073..10482975)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables pseudouridine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pseudouridine synthase activity	IEA Inferred from Electronic Annotation more info
enables pseudouridine synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	HMP more info	PubMed
involved_in enzyme-directed rRNA pseudouridine synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA pseudouridine synthesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of innate immune response	HMP more info	PubMed
involved_in pseudouridine synthesis	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RluA pseudouridine synthase 2

Names: CG6187-PA; CG6187-PC; CG6187-PD; CG6187-PE; RluA-2-PA; RluA-2-PC; RluA-2-PD; RluA-2-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

10477073..10482975

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_135567.4 → NP_609411.1 RluA pseudouridine synthase 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609411.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95TM3, Q9VKU8

Related

FBpp0079622

Conserved Domains (2) summary

cd02557
Location:202 → 386

PseudoU_synth_ScRIB2; Pseudouridine synthases similar to Saccharomyces cerevisiae RIB2

cd00165
Location:157 → 229

S4; S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized ...
NM_001201854.2 → NP_001188783.1 RluA pseudouridine synthase 2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188783.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MRH0

Conserved Domains (2) summary

cd02557
Location:202 → 386

PseudoU_synth_ScRIB2; Pseudouridine synthases similar to Saccharomyces cerevisiae RIB2

cd00165
Location:157 → 229

S4; S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized ...
NM_001273423.1 → NP_001260352.1 RluA pseudouridine synthase 2, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260352.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PFI9

Conserved Domains (1) summary

TIGR00005
Location:150 → 210

rluA_subfam; pseudouridine synthase, RluA family
NM_001201853.2 → NP_001188782.2 RluA pseudouridine synthase 2, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188782.2

Status: REVIEWED

UniProtKB/TrEMBL

Q95TM3, Q9VKU8

Conserved Domains (2) summary

cd02557
Location:202 → 386

PseudoU_synth_ScRIB2; Pseudouridine synthases similar to Saccharomyces cerevisiae RIB2

cd00165
Location:157 → 229

S4; S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized ...