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    lig lingerer [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35771, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ligprovided by FlyBase
    Official Full Name
    lingererprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020279
    Locus tag
    Dmel_CG8715
    See related
    AllianceGenome:FB:FBgn0020279
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8715; Dmel\CG8715
    Summary
    Involved in several processes, including dorsal/ventral axis specification, ovarian follicular epithelium; negative regulation of imaginal disc growth; and regulation of signal transduction. Located in P-body. Is expressed in adult head; embryonic/larval CNS subperineurial glial cell; larval brain; larval exit glial cell; and larval ventral nerve cord. Orthologous to several human genes including UBAP2L (ubiquitin associated protein 2 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See lig in Genome Data Viewer
    Location:
    44A4-44A4; 2-58 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8067977..8078815)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3955482..3966320)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 28 Neighboring gene saliva Neighboring gene sugar transporter 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression analysis of the lingerer gene in the larval central nervous system of Drosophila melanogaster. Kuniyoshi H, et al. J Neurogenet, 2003 Apr-Sep. PMID 14668197
    2. The Drosophila lingerer protein cooperates with Orb2 in long-term memory formation. Kimura S, et al. J Neurogenet, 2015 Mar. PMID 24913805
    3. The Drosophila fragile X protein functions as a negative regulator in the orb autoregulatory pathway. Costa A, et al. Dev Cell, 2005 Mar. PMID 15737929
    4. lingerer, a Drosophila gene involved in initiation and termination of copulation, encodes a set of novel cytoplasmic proteins. Kuniyoshi H, et al. Genetics, 2002 Dec. PMID 12524348, Free PMC Article
    5. The Drosophila hnRNP F/H homolog Glorund recruits dFMRP to inhibit nanos translation elongation. Peng Y, et al. Nucleic Acids Res, 2022 Jul 8. PMID 35699205, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study demonstrated that The Drosophila lingerer protein cooperates with Orb2 in long-term memory formation.
      Title: The Drosophila lingerer protein cooperates with Orb2 in long-term memory formation.
    2. lig may act in the nervous system to mediate the control of copulatory organs during courtship
      Title: lingerer, a Drosophila gene involved in initiation and termination of copulation, encodes a set of novel cytoplasmic proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in copulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal/ventral axis specification, ovarian follicular epithelium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in male mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of imaginal disc growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of hippo signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lingerer
    Names
    CG8715-PA
    CG8715-PB
    CG8715-PC
    CG8715-PD
    CG8715-PE
    CG8715-PF
    CG8715-PG
    CG8715-PH
    CG8715-PI
    CG8715-PJ
    CG8715-PK
    CG8715-PL
    lig-PA
    lig-PB
    lig-PC
    lig-PD
    lig-PE
    lig-PF
    lig-PG
    lig-PH
    lig-PI
    lig-PJ
    lig-PK
    lig-PL
    transcription unit A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8067977..8078815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206056.5 → NP_995778.2  lingerer, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995778.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86S05
      Conserved Domains (3) summary
      cd14277
      Location:85 → 122
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:575 → 607
      DUF3697; Ubiquitin-associated protein 2
      pfam15512
      Location:498 → 589
      CAF-1_p60_C; Chromatin assembly factor complex 1 subunit p60, C-terminal

    2. NM_165586.5 → NP_724643.2  lingerer, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724643.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JH02
      Conserved Domains (3) summary
      cd14277
      Location:85 → 122
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:575 → 607
      DUF3697; Ubiquitin-associated protein 2
      pfam15512
      Location:498 → 589
      CAF-1_p60_C; Chromatin assembly factor complex 1 subunit p60, C-terminal

    3. NM_001169612.2 → NP_001163083.1  lingerer, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163083.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JH02
      Conserved Domains (3) summary
      cd14277
      Location:85 → 122
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:575 → 607
      DUF3697; Ubiquitin-associated protein 2
      pfam15512
      Location:498 → 589
      CAF-1_p60_C; Chromatin assembly factor complex 1 subunit p60, C-terminal

    4. NM_136504.5 → NP_610348.3  lingerer, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610348.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86S05
      Conserved Domains (3) summary
      cd14277
      Location:85 → 122
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:575 → 607
      DUF3697; Ubiquitin-associated protein 2
      pfam15512
      Location:498 → 589
      CAF-1_p60_C; Chromatin assembly factor complex 1 subunit p60, C-terminal

    5. NM_001169610.2 → NP_001163081.1  lingerer, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163081.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JH02
      Conserved Domains (3) summary
      cd14277
      Location:85 → 122
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:575 → 607
      DUF3697; Ubiquitin-associated protein 2
      pfam15512
      Location:498 → 589
      CAF-1_p60_C; Chromatin assembly factor complex 1 subunit p60, C-terminal

    6. NM_001259270.2 → NP_001246199.1  lingerer, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246199.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7U5
      Conserved Domains (3) summary
      cd14277
      Location:85 → 122
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:575 → 607
      DUF3697; Ubiquitin-associated protein 2
      pfam15512
      Location:498 → 589
      CAF-1_p60_C; Chromatin assembly factor complex 1 subunit p60, C-terminal

    7. NM_001259271.2 → NP_001246200.1  lingerer, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246200.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6T1
      Conserved Domains (3) summary
      cd14277
      Location:85 → 122
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:575 → 607
      DUF3697; Ubiquitin-associated protein 2
      pfam15512
      Location:498 → 589
      CAF-1_p60_C; Chromatin assembly factor complex 1 subunit p60, C-terminal

    8. NM_001273866.2 → NP_001260795.1  lingerer, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260795.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFC5
      Conserved Domains (3) summary
      cd14277
      Location:85 → 122
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:575 → 607
      DUF3697; Ubiquitin-associated protein 2
      pfam15512
      Location:498 → 589
      CAF-1_p60_C; Chromatin assembly factor complex 1 subunit p60, C-terminal

    9. NM_001316409.1 → NP_001303338.1  lingerer, isoform L [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A126GUM8
      Conserved Domains (3) summary
      cd14277
      Location:85 → 122
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:575 → 607
      DUF3697; Ubiquitin-associated protein 2
      pfam15512
      Location:498 → 589
      CAF-1_p60_C; Chromatin assembly factor complex 1 subunit p60, C-terminal

    10. NM_001169611.1 → NP_001163082.1  lingerer, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163082.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JH02
      Conserved Domains (3) summary
      cd14277
      Location:85 → 122
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:575 → 607
      DUF3697; Ubiquitin-associated protein 2
      pfam15512
      Location:498 → 589
      CAF-1_p60_C; Chromatin assembly factor complex 1 subunit p60, C-terminal

    11. NM_001273865.1 → NP_001260794.1  lingerer, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260794.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0Z768
      Conserved Domains (3) summary
      cd14277
      Location:85 → 122
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:575 → 607
      DUF3697; Ubiquitin-associated protein 2
      pfam15512
      Location:498 → 589
      CAF-1_p60_C; Chromatin assembly factor complex 1 subunit p60, C-terminal

    12. NM_001014503.2 → NP_001014503.1  lingerer, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014503.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z794, Q86S05, Q86S06, Q8SZZ7
      Conserved Domains (3) summary
      cd14277
      Location:85 → 122
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:575 → 607
      DUF3697; Ubiquitin-associated protein 2
      pfam15512
      Location:498 → 589
      CAF-1_p60_C; Chromatin assembly factor complex 1 subunit p60, C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6T1 A0A0B4K6T1
    A0A0B4K7U5 A0A0B4K7U5
    A0A0B4KFC5 A0A0B4KFC5
    A0A126GUM8 A0A126GUM8
    D0Z768 D0Z768
    E1JH02 E1JH02
    Q86S05.1 Q86S05

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