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    Cpsf7 cleavage and polyadenylation specific factor 7 [ Mus musculus (house mouse) ]

    Gene ID: 269061, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cpsf7provided by MGI
    Official Full Name
    cleavage and polyadenylation specific factor 7provided by MGI
    Primary source
    MGI:MGI:1917826
    See related
    Ensembl:ENSMUSG00000034820 AllianceGenome:MGI:1917826
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730453I16Rik; C330017N18Rik
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway; mRNA alternative polyadenylation; and protein heterotetramerization. Predicted to be located in cytoplasm and nucleus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in several structures, including blastocyst; central nervous system; early embryo; olfactory epithelium; and retina. Orthologous to human CPSF7 (cleavage and polyadenylation specific factor 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 30.5), whole brain E14.5 (RPKM 27.5) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cpsf7 in Genome Data Viewer
    Location:
    19 A; 19 6.6 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10502594..10525099)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10525223..10547735)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene stabilizer of axonemal microtubules 4 Neighboring gene succinate dehydrogenase complex assembly factor 2 Neighboring gene transmembrane protein 216 Neighboring gene STARR-positive B cell enhancer ABC_E9455 Neighboring gene transmembrane protein 138 Neighboring gene cytochrome b561 family, member A3 Neighboring gene triokinase, FMN cyclase Neighboring gene STARR-positive B cell enhancer ABC_E5687 Neighboring gene damage specific DNA binding protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC46982

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA alternative polyadenylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mRNA alternative polyadenylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA alternative polyadenylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein heterotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein heterotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein tetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of mRNA cleavage and polyadenylation specificity factor complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of mRNA cleavage and polyadenylation specificity factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mRNA cleavage factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mRNA cleavage factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    cleavage and polyadenylation specificity factor subunit 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164272.2NP_001157744.1  cleavage and polyadenylation specificity factor subunit 7 isoform 2

      See identical proteins and their annotated locations for NP_001157744.1

      Status: VALIDATED

      Source sequence(s)
      AC125093
      UniProtKB/Swiss-Prot
      Q8BTV2
      Conserved Domains (1) summary
      cd12644
      Location:81170
      RRM_CFIm59; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and similar proteins
    2. NM_001362450.2NP_001349379.1  cleavage and polyadenylation specificity factor subunit 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC125093
    3. NM_172302.4NP_758506.3  cleavage and polyadenylation specificity factor subunit 7 isoform 1

      See identical proteins and their annotated locations for NP_758506.3

      Status: VALIDATED

      Source sequence(s)
      AC125093
      Consensus CDS
      CCDS29579.1
      UniProtKB/Swiss-Prot
      Q3TNF1, Q8BKE7, Q8BTV2, Q8CFS8
      Related
      ENSMUSP00000038958.4, ENSMUST00000038379.5
      Conserved Domains (2) summary
      COG0724
      Location:20231
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12644
      Location:81170
      RRM_CFIm59; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      10502594..10525099
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250956.2XP_030106816.1  cleavage and polyadenylation specificity factor subunit 7 isoform X4

      Conserved Domains (1) summary
      cl17169
      Location:23101
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. XM_006527117.4XP_006527180.1  cleavage and polyadenylation specificity factor subunit 7 isoform X3

      See identical proteins and their annotated locations for XP_006527180.1

      Conserved Domains (1) summary
      cl17169
      Location:23101
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. XM_036161607.1XP_036017500.1  cleavage and polyadenylation specificity factor subunit 7 isoform X4

      Conserved Domains (1) summary
      cl17169
      Location:23101
      RRM_SF; RNA recognition motif (RRM) superfamily
    4. XM_036161606.1XP_036017499.1  cleavage and polyadenylation specificity factor subunit 7 isoform X3

      Conserved Domains (1) summary
      cl17169
      Location:23101
      RRM_SF; RNA recognition motif (RRM) superfamily
    5. XM_030250955.1XP_030106815.1  cleavage and polyadenylation specificity factor subunit 7 isoform X3

      Conserved Domains (1) summary
      cl17169
      Location:23101
      RRM_SF; RNA recognition motif (RRM) superfamily
    6. XM_006527116.5XP_006527179.1  cleavage and polyadenylation specificity factor subunit 7 isoform X1

      See identical proteins and their annotated locations for XP_006527179.1

      UniProtKB/Swiss-Prot
      Q3TNF1, Q8BKE7, Q8BTV2, Q8CFS8
      Conserved Domains (2) summary
      COG0724
      Location:20231
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12644
      Location:81170
      RRM_CFIm59; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and similar proteins
    7. XM_030250954.1XP_030106814.1  cleavage and polyadenylation specificity factor subunit 7 isoform X2

      Conserved Domains (1) summary
      cd12644
      Location:81170
      RRM_CFIm59; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and similar proteins
    8. XM_006527119.2XP_006527182.1  cleavage and polyadenylation specificity factor subunit 7 isoform X3

      See identical proteins and their annotated locations for XP_006527182.1

      Conserved Domains (1) summary
      cl17169
      Location:23101
      RRM_SF; RNA recognition motif (RRM) superfamily
    9. XM_030250958.1XP_030106818.1  cleavage and polyadenylation specificity factor subunit 7 isoform X5

    10. XM_036161608.1XP_036017501.1  cleavage and polyadenylation specificity factor subunit 7 isoform X5