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    Wnt5b wingless-type MMTV integration site family, member 5B [ Mus musculus (house mouse) ]

    Gene ID: 22419, updated on 3-Dec-2024

    Summary

    Official Symbol
    Wnt5bprovided by MGI
    Official Full Name
    wingless-type MMTV integration site family, member 5Bprovided by MGI
    Primary source
    MGI:MGI:98959
    See related
    Ensembl:ENSMUSG00000030170 AllianceGenome:MGI:98959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wnt-5b
    Summary
    Enables signaling receptor binding activity. Acts upstream of or within negative regulation of canonical Wnt signaling pathway and positive regulation of fat cell differentiation. Located in cell surface and extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human WNT5B (Wnt family member 5B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 4.7), limb E14.5 (RPKM 3.9) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Wnt5b in Genome Data Viewer
    Location:
    6 F1; 6 56.86 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (119409493..119521847, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (119432531..119544824, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, alpha 2/delta subunit 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:119286263-119286553 Neighboring gene leucine-rich repeats and transmembrane domains 2 Neighboring gene STARR-positive B cell enhancer ABC_E9099 Neighboring gene adiponectin receptor 2 Neighboring gene STARR-seq mESC enhancer starr_17147 Neighboring gene STARR-seq mESC enhancer starr_17149 Neighboring gene predicted gene, 40397 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:119472087-119472240 Neighboring gene F-box and leucine-rich repeat protein 14 Neighboring gene predicted gene, 30690 Neighboring gene predicted gene, 52875 Neighboring gene ELKS/RAB6-interacting/CAST family member 1 Neighboring gene STARR-seq mESC enhancer starr_17152 Neighboring gene RIKEN cDNA 3110021A11 gene Neighboring gene STARR-seq mESC enhancer starr_17154 Neighboring gene family with sequence similarity 76, member A pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein Wnt-5b
    Names
    wingless-related MMTV integration site 5B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271757.2NP_001258686.1  protein Wnt-5b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AC126607
      Consensus CDS
      CCDS20474.2
      UniProtKB/Swiss-Prot
      P22726, Q91XF5
      UniProtKB/TrEMBL
      D3YTW9
      Related
      ENSMUSP00000113188.2, ENSMUST00000117171.8
      Conserved Domains (1) summary
      pfam00110
      Location:54359
      wnt; wnt family
    2. NM_001271758.2NP_001258687.1  protein Wnt-5b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AC126607
      Consensus CDS
      CCDS20474.2
      UniProtKB/Swiss-Prot
      P22726, Q91XF5
      UniProtKB/TrEMBL
      D3YTW9
      Related
      ENSMUSP00000112819.2, ENSMUST00000118120.8
      Conserved Domains (1) summary
      pfam00110
      Location:54359
      wnt; wnt family
    3. NM_001410505.1NP_001397434.1  protein Wnt-5b precursor

      Status: VALIDATED

      Source sequence(s)
      AC126607, AC128662
      UniProtKB/Swiss-Prot
      P22726, Q91XF5
      UniProtKB/TrEMBL
      D3YTW9
    4. NM_009525.4NP_033551.2  protein Wnt-5b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AC126607, AC128662
      Consensus CDS
      CCDS20474.2
      UniProtKB/Swiss-Prot
      P22726, Q91XF5
      UniProtKB/TrEMBL
      D3YTW9
      Related
      ENSMUSP00000137065.2, ENSMUST00000178696.8
      Conserved Domains (1) summary
      pfam00110
      Location:54359
      wnt; wnt family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      119409493..119521847 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166025.1XP_036021918.1  protein Wnt-5b isoform X1

      UniProtKB/TrEMBL
      D3YTW9
      Conserved Domains (1) summary
      cd19348
      Location:83394
      Wnt_Wnt5b; Wnt domain found in protein Wnt-5b and similar proteins
    2. XM_036166026.1XP_036021919.1  protein Wnt-5b isoform X2

      UniProtKB/TrEMBL
      A0A0R4J1M1, D3YTW9
      Conserved Domains (1) summary
      cd19348
      Location:61372
      Wnt_Wnt5b; Wnt domain found in protein Wnt-5b and similar proteins