Mis12 MIS12 kinetochore complex component [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mis12provided by MGI
Official Full Name: MIS12 kinetochore complex componentprovided by MGI
Primary source: MGI:MGI:1914389
See related: Ensembl:ENSMUSG00000040599 AllianceGenome:MGI:1914389
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Misc12; 2510025F08Rik
Summary: Predicted to be involved in attachment of mitotic spindle microtubules to kinetochore and kinetochore assembly. Predicted to be located in kinetochore and nucleus. Predicted to be part of MIS12/MIND type complex. Orthologous to human MIS12 (MIS12 kinetochore complex component). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 10.8), liver E14 (RPKM 7.9) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B4; 11 43.21 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (70910394..70918197)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (71019568..71027371)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mis12 controls cyclin B1 stabilization via Cdc14B-mediated APC/C(Cdh1) regulation during meiotic G2/M transition in mouse oocytes.
Title: Mis12 controls cyclin B1 stabilization via Cdc14B-mediated APC/C(Cdh1) regulation during meiotic G2/M transition in mouse oocytes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in attachment of mitotic spindle microtubules to kinetochore	ISS Inferred from Sequence or Structural Similarity more info
involved_in attachment of spindle microtubules to kinetochore	NAS Non-traceable Author Statement more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in kinetochore assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in kinetochore assembly	ISO Inferred from Sequence Orthology more info
involved_in kinetochore assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic sister chromatid segregation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MIS12/MIND type complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MIS12/MIND type complex	ISO Inferred from Sequence Orthology more info
part_of MIS12/MIND type complex	ISS Inferred from Sequence or Structural Similarity more info
part_of MIS12/MIND type complex	NAS Non-traceable Author Statement more info	PubMed
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	NAS Non-traceable Author Statement more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
located_in spindle pole	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: protein MIS12 homolog

Names: MIS12 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.