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    phoP two-component response regulator PhoP [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 879194, updated on 11-Sep-2024

    Summary

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    Gene symbol
    phoP
    Gene description
    two-component response regulator PhoP
    Locus tag
    PA1179
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (1277688..1278365)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene nitrate reductase protein NapE Neighboring gene PhoP/Q and low Mg2+ inducible outer membrane protein H1 Neighboring gene two-component sensor PhoQ Neighboring gene sensor protein Neighboring gene transcriptional regulator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa. Ernst RK, et al. Science, 1999 Nov 19. PMID 10567263
    2. PhoQ mutations promote lipid A modification and polymyxin resistance of Pseudomonas aeruginosa found in colistin-treated cystic fibrosis patients. Miller AK, et al. Antimicrob Agents Chemother, 2011 Dec. PMID 21968359, Free PMC Article
    3. Impact of two-component regulatory systems PhoP-PhoQ and PmrA-PmrB on colistin pharmacodynamics in Pseudomonas aeruginosa. Ly NS, et al. Antimicrob Agents Chemother, 2012 Jun. PMID 22470116, Free PMC Article
    4. Magnesium limitation is an environmental trigger of the Pseudomonas aeruginosa biofilm lifestyle. Mulcahy H, et al. PLoS One, 2011. PMID 21858064, Free PMC Article
    5. Contribution of the PhoP-PhoQ and PmrA-PmrB two-component regulatory systems to Mg2+-induced gene regulation in Pseudomonas aeruginosa. McPhee JB, et al. J Bacteriol, 2006 Jun. PMID 16707691, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The interaction of wild-type (WT) bacteria that had adhered to epithelial cells led to a large upregulation of the expression of the oprH-phoP-phoQ operon, in a PhoQ-dependent manner
      Title: The Pseudomonas aeruginosa PhoP-PhoQ two-component regulatory system is induced upon interaction with epithelial cells and controls cytotoxicity and inflammation.
    2. Colistin killing at subinhibitory concentrations was greater against the phoP and pmrA mutants than the wild type within the first 8 h.
      Title: Impact of two-component regulatory systems PhoP-PhoQ and PmrA-PmrB on colistin pharmacodynamics in Pseudomonas aeruginosa.
    3. Data suggest that PhoPQ controls the equilibrium of the small regulatory RNAs and thus fine-tunes the expression of genes in the RetS pathway.
      Title: Magnesium limitation is an environmental trigger of the Pseudomonas aeruginosa biofilm lifestyle.
    4. Results suggest that polymyxin B resistance among clinical isolates of P. aeruginosa is associated with alterations in two-component regulatory systems of phoPQ or pmrAB.
      Title: Alterations in two-component regulatory systems of phoPQ and pmrAB are associated with polymyxin B resistance in clinical isolates of Pseudomonas aeruginosa.
    5. Only a modest subset of the Mg(2+)-regulated genes were regulated through either PhoP or PmrA.
      Title: Contribution of the PhoP-PhoQ and PmrA-PmrB two-component regulatory systems to Mg2+-induced gene regulation in Pseudomonas aeruginosa.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to antibiotic ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of phospholipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    two-component response regulator PhoP
    NP_249870.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      1277688..1278365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_249870.1 two-component response regulator PhoP [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_249870.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0N9R2K7, A0A0N9R2Y2, G9JL95, G9JLA1
      Conserved Domains (1) summary
      PRK10816
      Location:1 → 220
      PRK10816; two-component system response regulator PhoP
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I4F9.1

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials