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    wbpB UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 882642, updated on 11-Sep-2024

    Summary

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    Gene symbol
    wbpB
    Gene description
    UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase
    Locus tag
    PA3158
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (3542740..3543690, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase Neighboring gene UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronate N-acetyltransferase Neighboring gene acetyltransferase Neighboring gene UDP-N-acetyl-d-glucosamine 6-dehydrogenase Neighboring gene O-antigen chain length regulator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of age, neuropsychological impairment, and medication on regional cerebral blood flow in schizophrenia and major affective disorder. Goldstein PC, et al. Henry Ford Hosp Med J, 1990. PMID 1982284
    2. Biosynthesis of a rare di-N-acetylated sugar in the lipopolysaccharides of both Pseudomonas aeruginosa and Bordetella pertussis occurs via an identical scheme despite different gene clusters. Westman EL, et al. J Bacteriol, 2008 Sep. PMID 18621892, Free PMC Article
    3. Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1. Larkin A, et al. Biochemistry, 2009 Jun 16. PMID 19348502, Free PMC Article
    4. Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas aeruginosa. Westman EL, et al. J Biol Chem, 2009 May 1. PMID 19282284, Free PMC Article
    5. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB enzyme in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1
      Title: Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables NADH dehydrogenase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within O antigen biosynthetic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within UDP-glucuronate biosynthetic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within polysaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase
    NP_251848.1
    • Product name confidence: class 1: Function experimentally demonstrated in P. aeruginosa

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      3542740..3543690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_251848.1 UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_251848.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      G3XD23
      Conserved Domains (2) summary
      pfam01408
      Location:2 → 125
      GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
      pfam02894
      Location:150 → 309
      GFO_IDH_MocA_C; Oxidoreductase family, C-terminal alpha/beta domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3XD23.1

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials