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    amrZ alginate and motility regulator Z [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 878714, updated on 11-Sep-2024

    Summary

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    Gene symbol
    amrZ
    Gene description
    alginate and motility regulator Z
    Locus tag
    PA3385
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (3791347..3791673)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene phosphonate ABC transporter substrate-binding protein Neighboring gene phosphonate ABC transporter ATP-binding protein Neighboring gene hypothetical protein Neighboring gene 3-oxoacyl-ACP reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ChIP-Seq and RNA-Seq reveal an AmrZ-mediated mechanism for cyclic di-GMP synthesis and biofilm development by Pseudomonas aeruginosa. Jones CJ, et al. PLoS Pathog, 2014 Mar. PMID 24603766, Free PMC Article
    2. The AlgT-dependent transcriptional regulator AmrZ (AlgZ) inhibits flagellum biosynthesis in mucoid, nonmotile Pseudomonas aeruginosa cystic fibrosis isolates. Tart AH, et al. J Bacteriol, 2006 Sep. PMID 16952938, Free PMC Article
    3. Pseudomonas aeruginosa AlgZ, a ribbon-helix-helix DNA-binding protein, is essential for alginate synthesis and algD transcriptional activation. Baynham PJ, et al. Mol Microbiol, 1999 Sep. PMID 10476040
    4. AmrZ modulates Pseudomonas aeruginosa biofilm architecture by directly repressing transcription of the psl operon. Jones CJ, et al. J Bacteriol, 2013 Apr. PMID 23354748, Free PMC Article
    5. The Pseudomonas aeruginosa ribbon-helix-helix DNA-binding protein AlgZ (AmrZ) controls twitching motility and biogenesis of type IV pili. Baynham PJ, et al. J Bacteriol, 2006 Jan. PMID 16352829, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RsmA and AmrZ have roles in orchestrating assembly of all three type VI secretion systems in Pseudomonas aeruginosa
      Title: RsmA and AmrZ orchestrate the assembly of all three type VI secretion systems in Pseudomonas aeruginosa.
    2. we identified a c-di-GMP mediated mechanism for AmrZ regulation of P. aeruginosa biofilm formation and chronicity.
      Title: ChIP-Seq and RNA-Seq reveal an AmrZ-mediated mechanism for cyclic di-GMP synthesis and biofilm development by Pseudomonas aeruginosa.
    3. These observations support the hypothesis that AmrZ is a multifunctional regulator mediating transition of P. aeruginosa biofilm infections from colonizing to chronic biofilms through repression of the psl operon while activating the algD operon.
      Title: AmrZ modulates Pseudomonas aeruginosa biofilm architecture by directly repressing transcription of the psl operon.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within bacterial-type flagellum assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of bacterial-type flagellum-dependent cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of single-species biofilm formation on inanimate substrate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of single-species biofilm formation on inanimate substrate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of polysaccharide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within type IV pilus-dependent motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alginate and motility regulator Z
    NP_252075.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      3791347..3791673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_252075.1 alginate and motility regulator Z [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_252075.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      G3XCY4
      Conserved Domains (1) summary
      pfam03869
      Location:13 → 62
      Arc; Arc-like DNA binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3XCY4.1

    Gene LinkOut

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