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    Gpdh3 Glycerol-3-phosphate dehydrogenase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42624, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpdh3provided by FlyBase
    Official Full Name
    Glycerol-3-phosphate dehydrogenase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0263048
    Locus tag
    Dmel_CG43343
    See related
    AllianceGenome:FB:FBgn0263048
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18427; CG31169; CG43343; Dmel\CG43343; gpdh-3; GPDH-3; NEST:bs15d11; NEST:bs16c09
    Old locus tag
    Dmel_CG31169
    Summary
    Predicted to enable glycerol-3-phosphate dehydrogenase (NAD+) activity. Predicted to be involved in NADH oxidation and glycerol-3-phosphate metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Brugada syndrome 2. Orthologous to human GPD1 (glycerol-3-phosphate dehydrogenase 1) and GPD1L (glycerol-3-phosphate dehydrogenase 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gpdh3 in Genome Data Viewer
    Location:
    94A6-94A11; 3-74 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22382035..22386548)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18207757..18212270)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Carbonic anhydrase 8 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Serine-GCT 2-3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Candidate transcriptomic sources of inbreeding depression in Drosophila melanogaster. Garcia C, et al. PLoS One, 2013. PMID 23922905, Free PMC Article
    2. Direct Testing for Allele-Specific Expression Differences Between Conditions. León-Novelo L, et al. G3 (Bethesda), 2018 Feb 2. PMID 29167272, Free PMC Article
    3. Genomic signatures of globally enhanced gene duplicate accumulation in the megadiverse higher Diptera fueling intralocus sexual conflict resolution. Bao R, et al. PeerJ, 2020. PMID 33083121, Free PMC Article
    4. The alpha glycerophosphate cycle in Drosophila melanogaster VI. structure and evolution of enzyme paralogs in the genus Drosophila. Carmon A, et al. J Hered, 2010 Mar-Apr. PMID 19995805
    5. Behavioral screening of sleep-promoting effects of human intestinal and food-associated bacteria on Drosophila melanogaster. Ko T, et al. Genes Cells, 2023 Jun. PMID 36914986, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphate dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADH oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NADH oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol-3-phosphate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol-3-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerol-3-phosphate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Glycerol-3-phosphate dehydrogenase 3
    Names
    CG43343-PA
    CG43343-PB
    CG43343-PC
    Gpdh3-PA
    Gpdh3-PB
    Gpdh3-PC
    alpha glycerophosphate dehydrogenase 3
    NP_001163685.1
    NP_732725.2
    NP_732726.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22382035..22386548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170214.2 → NP_001163685.1  Glycerol-3-phosphate dehydrogenase 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163685.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIT1, Q8T8S8
      Conserved Domains (4) summary
      TIGR03376
      Location:6 → 312
      glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
      pfam07479
      Location:195 → 312
      NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
      pfam15808
      Location:948 → 1096
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
      cl21454
      Location:6 → 174
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_170006.4 → NP_732726.2  Glycerol-3-phosphate dehydrogenase 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732726.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IN06, Q8T8S8
      Related
      FBpp0297798
      Conserved Domains (4) summary
      TIGR03376
      Location:6 → 342
      glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
      pfam07479
      Location:195 → 336
      NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
      pfam15808
      Location:961 → 1109
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
      cl21454
      Location:6 → 174
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. NM_170005.3 → NP_732725.2  Glycerol-3-phosphate dehydrogenase 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732725.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T8S8, Q9VD20
      Conserved Domains (4) summary
      TIGR03376
      Location:6 → 342
      glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
      pfam07479
      Location:195 → 336
      NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
      pfam15808
      Location:960 → 1108
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
      cl21454
      Location:6 → 174
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JIT1 E1JIT1
    Q8IN06 Q8IN06
    Q9VD20 Q9VD20

    Gene LinkOut

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