BigH1 Histone H1 variant BigH1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: BigH1provided by FlyBase
Official Full Name: Histone H1 variant BigH1provided by FlyBase
Primary source: FLYBASE:FBgn0038252
Locus tag: Dmel_CG3509
See related: AllianceGenome:FB:FBgn0038252
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Big H1; CG3509; dBigH1; Dmel\CG3509
Summary: Enables nucleosome binding activity. A structural constituent of chromatin. Involved in negative regulation of DNA-templated transcription. Located in chromatin. Is expressed in several structures, including germline cell; gonad; larval muscle system; larval somatic muscle cell; and pole plasm. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 88C10-88C10; 3-55 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (14663450..14664822)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (10489172..10490544)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The tumour suppressor brain tumour (Brat) regulates linker histone dBigH1 expression in the Drosophila female germline and the early embryo.
Title: The tumour suppressor brain tumour (Brat) regulates linker histone dBigH1 expression in the Drosophila female germline and the early embryo.
Alternative linker histone permits fast paced nuclear divisions in early Drosophila embryo.
Title: Alternative linker histone permits fast paced nuclear divisions in early Drosophila embryo.
The results suggest that the negatively charged N-terminal tail of dBigH1 alters the functional state of active chromatin compromising transcription.
Title: The embryonic linker histone dBigH1 alters the functional state of active chromatin.
The germline linker histone dBigH1 and the translational regulator Bam form a repressor loop essential for male germ stem cell differentiation.
Title: The Germline Linker Histone dBigH1 and the Translational Regulator Bam Form a Repressor Loop Essential for Male Germ Stem Cell Differentiation.
H1 is intrinsically required in the regulation of germline stem cells in the Drosophila ovary.
Title: Histone H1-mediated epigenetic regulation controls germline stem cell self-renewal by modulating H4K16 acetylation.
The presence of unusual acidic amino acid patches at the N-terminal end of dBigH1 is in contrast to the arginine patches that exist at the N- and C-terminal domains of other histone H1-related proteins found in the sperm of some organisms. [review]
Title: dBigH1, a second histone H1 in Drosophila, and the consequences for histone fold nomenclature.
The results show an essential function of dBigH1 (CG3509 product)in zygotic genome activation regulation.
Title: The embryonic linker histone H1 variant of Drosophila, dBigH1, regulates zygotic genome activation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables nucleosome binding	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of chromatin	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleosome assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
part_of nucleosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: histone H1

Names: BigH1-PA; CG3509-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

14663450..14664822

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_142126.2 → NP_650383.2 histone H1 variant BigH1 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650383.2

Status: REVIEWED

UniProtKB/TrEMBL

A0APA8, Q8MSC4, Q9VFH1

Related

FBpp0082428

Conserved Domains (1) summary

cl00073
Location:109 → 167

H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...