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    RtcB RtcB RNA ligase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35220, updated on 9-Dec-2024

    Summary

    Official Symbol
    RtcBprovided by FlyBase
    Official Full Name
    RtcB RNA ligaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032781
    Locus tag
    Dmel_CG9987
    See related
    AllianceGenome:FB:FBgn0032781
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9987; Dmel\CG9987; Rtcb
    Summary
    Predicted to enable RNA ligase (GTP) activity. Involved in positive regulation of tRNA processing and tRNA processing. Predicted to be part of tRNA-splicing ligase complex. Predicted to be active in nucleus. Is expressed in adult head. Orthologous to human RTCB (RNA 2',3'-cyclic phosphate and 5'-OH ligase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See RtcB in Genome Data Viewer
    Location:
    37E1-37E1; 2-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19430643..19432444)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19430643..19432444)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Paxillin Neighboring gene lectin-37Db Neighboring gene uncharacterized protein Neighboring gene Alkaline phosphatase 12 Neighboring gene Rab9 Neighboring gene uncharacterized protein Neighboring gene Ran GTPase activating protein

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    is_active_in nucleus  
    part_of tRNA-splicing ligase complex  
    part_of tRNA-splicing ligase complex  

    General protein information

    Preferred Names
    RtcB RNA ligase
    Names
    CG9987-PA
    RtcB-PA
    RtcB-like
    NP_609965.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19430643..19432444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136121.2 → NP_609965.1  RtcB RNA ligase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609965.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VIW7
      Related
      FBpp0080746
      Conserved Domains (2) summary
      COG1690
      Location:67 → 506
      RtcB; RNA-splicing ligase RtcB, repairs tRNA damage [Translation, ribosomal structure and biogenesis]
      pfam01139
      Location:67 → 506
      RtcB; tRNA-splicing ligase RtcB
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