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    brk brinker [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31665, updated on 17-Dec-2024

    Summary

    Official Symbol
    brkprovided by FlyBase
    Official Full Name
    brinkerprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024250
    Locus tag
    Dmel_CG9653
    See related
    AllianceGenome:FB:FBgn0024250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Brk; BRK; CG9653; Dm brk; Dmel\CG9653; ssg-1
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell competition in a multicellular organism; negative regulation of BMP signaling pathway; and posterior Malpighian tubule development. Located in nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; germ layer; head epidermis primordium; imaginal disc; and tracheal primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See brk in Genome Data Viewer
    Location:
    7B1-7B1; 1-20 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7307939..7311132)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7201972..7205165)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44357 Neighboring gene uncharacterized protein Neighboring gene unc-119 Neighboring gene uncharacterized protein Neighboring gene Autophagy-related 5 Neighboring gene Downstream of kinase

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    General protein information

    Preferred Names
    brinker
    Names
    CG9653-PA
    brk-PA
    small salivary glands-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7307939..7311132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078514.4NP_511069.3  brinker [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511069.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DN74, Q9XTN4
      Related
      FBpp0071007
      Conserved Domains (1) summary
      pfam09607
      Location:43100
      BrkDBD; Brinker DNA-binding domain