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    CG42514 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 8674108, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG42514provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260388
    Locus tag
    Dmel_CG42514
    See related
    AllianceGenome:FB:FBgn0260388
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AC; CG32158; CG4526; Dmel\CG42514
    Old locus tag
    Dmel_CG32158
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in several structures, including adult head; embryonic central brain neurons; embryonic dorsal epidermis; ganglia; and larval nervous system. Human ortholog(s) of this gene implicated in hereditary folate malabsorption. Orthologous to human SLC46A1 (solute carrier family 46 member 1) and SLC46A3 (solute carrier family 46 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG42514 in Genome Data Viewer
    Location:
    73A3-73A3; 3-44 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16491838..16496236, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16484938..16489336, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene doublesex cognate 73A Neighboring gene argos Neighboring gene uncharacterized protein Neighboring gene scarlet Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Learning defects in Drosophila growth restricted chico mutants are caused by attenuated adenylyl cyclase activity. Naganos S, et al. Mol Brain, 2016 Apr 6. PMID 27048332, Free PMC Article
    2. Adenylyl cyclase encoded by AC78C participates in sugar perception in Drosophila melanogaster. Ueno K, et al. Eur J Neurosci, 2008 Nov. PMID 19046378
    3. SLC46 Family Transporters Facilitate Cytosolic Innate Immune Recognition of Monomeric Peptidoglycans. Paik D, et al. J Immunol, 2017 Jul 1. PMID 28539433, Free PMC Article
    4. Protein kinases and phosphatases in the Drosophila genome. Morrison DK, et al. J Cell Biol, 2000 Jul 24. PMID 10908587, Free PMC Article
    5. The Identification and Evolutionary Trends of the Solute Carrier Superfamily in Arthropods. Denecke SM, et al. Genome Biol Evol, 2020 Aug 1. PMID 32681801, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: c16494489-16494049 mobile_element_type = transposon:jockey{}1013

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42514-PA
    CG42514-PB
    CG42514-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16491838..16496236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168669.2 → NP_730172.1  uncharacterized protein Dmel_CG42514, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730172.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8E1, Q960A8
      Conserved Domains (2) summary
      cd06174
      Location:132 → 495
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:129 → 458
      MFS_1; Major Facilitator Superfamily

    2. NM_168668.2 → NP_730171.1  uncharacterized protein Dmel_CG42514, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730171.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8E1, Q960A8
      Conserved Domains (2) summary
      cd06174
      Location:132 → 495
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:129 → 458
      MFS_1; Major Facilitator Superfamily

    3. NM_140642.3 → NP_648899.2  uncharacterized protein Dmel_CG42514, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648899.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960A8, Q9I7R2
      Conserved Domains (2) summary
      cd06174
      Location:130 → 493
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:127 → 456
      MFS_1; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E8E1 Q0E8E1
    Q9I7R2 Q9I7R2

    Gene LinkOut

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