Arg1 arginase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arg1provided by RGD
Official Full Name: arginase 1provided by RGD
Primary source: RGD:2150
See related: EnsemblRapid:ENSRNOG00000013304 AllianceGenome:RGD:2150
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables arginase activity; identical protein binding activity; and manganese ion binding activity. Involved in several processes, including arginine catabolic process to ornithine; cellular response to dexamethasone stimulus; and cellular response to glucagon stimulus. Located in extracellular space; mitochondrial outer membrane; and neuronal cell body. Used to study acute necrotizing pancreatitis and hypertension. Biomarker of several diseases, including acute kidney failure; cholestasis; silicosis; ureteral obstruction; and uveitis. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 3507.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 1p12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (22295093..22307720)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (20475878..20488422)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (21525421..21537872)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arginase 1 expression is increased during hepatic stellate cell activation and facilitates collagen synthesis.
Title: Arginase 1 expression is increased during hepatic stellate cell activation and facilitates collagen synthesis.
Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus
Title: Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus.
Arg1 expression, which is abundant in polarized M2 cells, is associated with strain/genotype differences from different pathways.
Title: Genotype-Associated Arginase 1 Expression in Rat Peritoneal Macrophages Induced by Toxoplasma gondii.
Intermittent hypoxia increases expression levels of arginase I and II proteins in adult rats.
Title: Pulmonary arterial hypertension in rats due to age-related arginase activation in intermittent hypoxia.
Arginase promotes endothelial dysfunction and hypertension in obesity by reducing arginine bioavailability.
Title: Arginase promotes endothelial dysfunction and hypertension in obese rats.
Lower activity and expression levels of iNOS and higher activity and expression levels of arginase-1 in rat alveolar macrophages were found to be linked to the susceptibility of T. gondii infection in these cells
Title: Lower expression of inducible nitric oxide synthase and higher expression of arginase in rat alveolar macrophages are linked to their susceptibility to Toxoplasma gondii infection.
arginase 1 and 2 inhibition augmented iNOS-dependent NO production that resulted in suppression of IL-1beta-induced vascular smooth muscle cell proliferation in a cGMP-dependent manner
Title: Arginase inhibition reduces interleukin-1β-stimulated vascular smooth muscle cell proliferation by increasing nitric oxide synthase-dependent nitric oxide production.
Diabetes-induced increases in arginase I were involved in the diabetes-induced impairment of retinal blood flow by a mechanism involving vascular endothelial cell dysfunction.
Title: The role of arginase I in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes.
Report utility of arginase-1 for monitoring drug-induced liver injury in rat model.
Title: A performance evaluation of three drug-induced liver injury biomarkers in the rat: alpha-glutathione S-transferase, arginase 1, and 4-hydroxyphenyl-pyruvate dioxygenase.
Arginase and methylated arginine derivatives appear to be essential modulators of the inflammatory response in the acute phase of a multiple sclerosis model.
Title: Modulation of nitric oxide synthase by arginase and methylated arginines during the acute phase of experimental multiple sclerosis.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Arg1 (e-PCR), detects polymorphism
- UniSTS:141121

RH134303 (e-PCR)
- UniSTS:217585

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arginase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arginase activity	IDA Inferred from Direct Assay more info	PubMed
enables arginase activity	IEA Inferred from Electronic Annotation more info
enables arginase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables manganese ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables manganese ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in arginine catabolic process to ornithine	IBA Inferred from Biological aspect of Ancestor more info
involved_in arginine catabolic process to ornithine	IDA Inferred from Direct Assay more info	PubMed
involved_in arginine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in arginine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucagon stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interleukin-4	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in collagen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to protozoan	IEA Inferred from Electronic Annotation more info
involved_in defense response to protozoan	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in lung development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mammary gland involution	IEP Inferred from Expression Pattern more info	PubMed
involved_in maternal process involved in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T-helper 2 cell cytokine production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T-helper 2 cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of activated T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of type II interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neutrophil mediated killing of fungus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neutrophil mediated killing of fungus	ISO Inferred from Sequence Orthology more info
involved_in regulation of L-arginine import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in response to amine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to axon injury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to herbicide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to manganese ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to methylmercury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nematode	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to nematode	ISO Inferred from Sequence Orthology more info
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to selenium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin E	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in urea cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in urea cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: arginase-1

Names: AI type I arginase; arginase, liver; liver-type arginase; type I arginase

NP_058830.2

EC 3.5.3.1

XP_038959286.1

EC 3.5.3.1

XP_038959290.1

EC 3.5.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017134.3 → NP_058830.2 arginase-1

See identical proteins and their annotated locations for NP_058830.2

Status: VALIDATED

Source sequence(s)

FM100195, FM120421, JAXUCZ010000001

UniProtKB/Swiss-Prot

P07824, Q5BK93

Related

ENSRNOP00000017911.4, ENSRNOT00000017911.7

Conserved Domains (1) summary

cd11587
Location:9 → 303

Arginase-like; Arginase types I and II and arginase-like family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

22295093..22307720

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103358.2 → XP_038959286.1 arginase-1 isoform X1

UniProtKB/TrEMBL

A0A8L2Q8Y7, A6JUJ9

Conserved Domains (1) summary

cd11587
Location:21 → 315

Arginase-like; Arginase types I and II and arginase-like family
XM_039103362.2 → XP_038959290.1 arginase-1 isoform X2

Conserved Domains (1) summary

cl17011
Location:1 → 201

Arginase_HDAC; Arginase-like and histone-like hydrolases