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    Pdk3 pyruvate dehydrogenase kinase, isoenzyme 3 [ Mus musculus (house mouse) ]

    Gene ID: 236900, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pdk3provided by MGI
    Official Full Name
    pyruvate dehydrogenase kinase, isoenzyme 3provided by MGI
    Primary source
    MGI:MGI:2384308
    See related
    Ensembl:ENSMUSG00000035232 AllianceGenome:MGI:2384308
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610001M10Rik
    Summary
    Predicted to enable ATP binding activity; protein serine/threonine kinase activity; and pyruvate dehydrogenase (acetyl-transferring) kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; peptidyl-serine phosphorylation; and regulation of acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked dominant 6. Orthologous to human PDK3 (pyruvate dehydrogenase kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 17.7), limb E14.5 (RPKM 10.6) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pdk3 in Genome Data Viewer
    Location:
    X C3; X 41.34 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (92798923..92875756, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (93764616..93832150, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 6985 Neighboring gene STARR-seq mESC enhancer starr_47550 Neighboring gene STARR-seq mESC enhancer starr_47551 Neighboring gene phosphate cytidylyltransferase 1, choline, beta isoform Neighboring gene predicted gene, 35641 Neighboring gene SPT20 SAGA complex component, pseudogene Neighboring gene predicted gene 15164

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC6383

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to fatty acid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to fatty acid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hypoxia-inducible factor-1alpha signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hypoxia-inducible factor-1alpha signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peroxisome proliferator activated receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peroxisome proliferator activated receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of acetyl-CoA biosynthetic process from pyruvate IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of acetyl-CoA biosynthetic process from pyruvate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of acetyl-CoA biosynthetic process from pyruvate ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of glucose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of reactive oxygen species metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    pyruvate dehydrogenase kinase, isozyme 3
    Names
    [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial
    [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial
    NP_663605.1
    XP_036017817.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145630.3NP_663605.1  pyruvate dehydrogenase kinase, isozyme 3

      See identical proteins and their annotated locations for NP_663605.1

      Status: VALIDATED

      Source sequence(s)
      AL589652
      Consensus CDS
      CCDS30275.1
      UniProtKB/Swiss-Prot
      Q8BTX1, Q922H2
      UniProtKB/TrEMBL
      Q3V250, Q4FJR4
      Related
      ENSMUSP00000036604.7, ENSMUST00000045748.7
      Conserved Domains (3) summary
      smart00387
      Location:238359
      HATPase_c; Histidine kinase-like ATPases
      COG0642
      Location:220365
      BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
      pfam10436
      Location:26188
      BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      92798923..92875756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161924.1XP_036017817.1  pyruvate dehydrogenase kinase, isozyme 3 isoform X1

      UniProtKB/TrEMBL
      Q3V250
      Conserved Domains (2) summary
      cd16929
      Location:146313
      HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
      pfam10436
      Location:2142
      BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase