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    Zfp248 zinc finger protein 248 [ Mus musculus (house mouse) ]

    Gene ID: 72720, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zfp248provided by MGI
    Official Full Name
    zinc finger protein 248provided by MGI
    Primary source
    MGI:MGI:1919970
    See related
    Ensembl:ENSMUSG00000030145 AllianceGenome:MGI:1919970
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810037F07Rik; E130106N01Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in cortical plate; limb; and trunk somite. Orthologous to human ZNF248 (zinc finger protein 248). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 2.7), CNS E18 (RPKM 2.6) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Zfp248 in Genome Data Viewer
    Location:
    6 F1; 6 55.86 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (118404280..118432660, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (118427319..118455699, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30498 Neighboring gene STARR-seq mESC enhancer starr_17136 Neighboring gene BMS1, ribosome biogenesis factor Neighboring gene zinc finger protein 9 Neighboring gene zinc finger protein 248 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361899.1NP_001348828.1  zinc finger protein 248 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AC140192
      Consensus CDS
      CCDS90111.1
      UniProtKB/TrEMBL
      Q9CZ86
      Conserved Domains (3) summary
      COG5048
      Location:302368
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:390410
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:430455
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001361900.1NP_001348829.1  zinc finger protein 248 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AC140192, AK012874, BC082571
      Consensus CDS
      CCDS90111.1
      UniProtKB/TrEMBL
      Q9CZ86
      Related
      ENSMUSP00000124539.2, ENSMUST00000161519.8
      Conserved Domains (3) summary
      COG5048
      Location:302368
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:390410
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:430455
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001361901.1NP_001348830.1  zinc finger protein 248 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AC140192, BC082571, CA750367
      Consensus CDS
      CCDS90111.1
      UniProtKB/TrEMBL
      Q9CZ86
      Conserved Domains (3) summary
      COG5048
      Location:302368
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:390410
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:430455
      zf-H2C2_2; Zinc-finger double domain
    4. NM_028335.2NP_082611.1  zinc finger protein 248 isoform a

      See identical proteins and their annotated locations for NP_082611.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC140192, BC082571
      Consensus CDS
      CCDS51884.1
      UniProtKB/TrEMBL
      Q640N4
      Related
      ENSMUSP00000068807.8, ENSMUST00000069292.14
      Conserved Domains (4) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:403469
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:491511
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:531556
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      118404280..118432660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152325.1XP_036008218.1  zinc finger protein 248 isoform X1

      UniProtKB/TrEMBL
      Q640N4
      Conserved Domains (4) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:403469
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:491511
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:531556
      zf-H2C2_2; Zinc-finger double domain
    2. XM_006506676.3XP_006506739.1  zinc finger protein 248 isoform X1

      See identical proteins and their annotated locations for XP_006506739.1

      UniProtKB/TrEMBL
      Q640N4
      Conserved Domains (4) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:403469
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:491511
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:531556
      zf-H2C2_2; Zinc-finger double domain
    3. XM_036152327.1XP_036008220.1  zinc finger protein 248 isoform X2

      UniProtKB/TrEMBL
      Q9CZ86
      Conserved Domains (3) summary
      COG5048
      Location:302368
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:390410
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:430455
      zf-H2C2_2; Zinc-finger double domain
    4. XM_036152328.1XP_036008221.1  zinc finger protein 248 isoform X2

      UniProtKB/TrEMBL
      Q9CZ86
      Conserved Domains (3) summary
      COG5048
      Location:302368
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:390410
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:430455
      zf-H2C2_2; Zinc-finger double domain
    5. XM_030255603.1XP_030111463.1  zinc finger protein 248 isoform X2

      UniProtKB/TrEMBL
      Q9CZ86
      Conserved Domains (3) summary
      COG5048
      Location:302368
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:390410
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:430455
      zf-H2C2_2; Zinc-finger double domain
    6. XM_036152326.1XP_036008219.1  zinc finger protein 248 isoform X2

      UniProtKB/TrEMBL
      Q9CZ86
      Conserved Domains (3) summary
      COG5048
      Location:302368
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:390410
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:430455
      zf-H2C2_2; Zinc-finger double domain
    7. XM_030255604.2XP_030111464.1  zinc finger protein 248 isoform X2

      UniProtKB/TrEMBL
      Q9CZ86
      Conserved Domains (3) summary
      COG5048
      Location:302368
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:390410
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:430455
      zf-H2C2_2; Zinc-finger double domain