Muc4 mucin 4, cell surface associated [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Muc4provided by RGD
Official Full Name: mucin 4, cell surface associatedprovided by RGD
Primary source: RGD:621331
See related: EnsemblRapid:ENSRNOG00000089703 AllianceGenome:RGD:621331
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Psmc; ASGP-1
Summary: Enables ErbB-2 class receptor binding activity. Involved in several processes, including estrous cycle; negative regulation of T cell mediated cytotoxicity directed against tumor cell target; and negative regulation of cell adhesion. Located in apical plasma membrane; extracellular space; and microvillus membrane. Part of protein-containing complex. Biomarker of cholangiocarcinoma; corneal neovascularization; mucositis; and otitis media. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human MUC4 (mucin 4, cell surface associated). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 117.2), Adrenal (RPKM 11.1) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 11q22

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (81513321..81575200, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (68008245..68053242, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (71242973..71285217, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Muc4 precursor is synthesized in all layers of the corneal epithelium, but Muc4 is degraded in basal and intermediate layers by a proteosomal mechanism at least partly dependent on TGF-beta inhibition of Muc4 processing.
Title: Regulation of the membrane mucin Muc4 in corneal epithelial cells by proteosomal degradation and TGF-beta.
TGFbeta inhibits Muc4 precursor cleavage, shunting the precursor into the proteosomal degradation pathway.
Title: TGFbeta regulation of membrane mucin Muc4 via proteosome degradation.
Since Muc4/SMC has been shown to be a potent anti-adhesive and a repressor of apoptosis, we propose that it plays a role in the non-apoptotic desquamation process.
Title: Non-apoptotic desquamation of cells from corneal epithelium: putative role for Muc4/sialomucin complex in cell release and survival.
These data provide further evidence of the ability of Muc4/SMC to interact with ErbB2 and influence its behavior in normal epithelia in mammary gland during pregnancy
Title: Expression, location, and interactions of ErbB2 and its intramembrane ligand Muc4 (sialomucin complex) in rat mammary gland during pregnancy.
post-translational regulation via transforming growth factor-beta and interferon-gamma pathways in rat mammary epithelial cells involves SMAD2 and SMAD7
Title: SMAD2 and SMAD7 involvement in the post-translational regulation of Muc4 via the transforming growth factor-beta and interferon-gamma pathways in rat mammary epithelial cells.
Muc4/SMC, role in cell regulation through ErbB signaling. Review.
Title: ErbB2 and its ligand Muc4 (sialomucin complex) in rat lacrimal gland.
As a luminal surface component, the MUC4 is situated to contribute to the non-adhesive luminal surface and to act as an intrinsic protection and survival factor for blood vessels
Title: Presence of MUC4 in human milk and at the luminal surfaces of blood vessels.
membrane mucin Muc4/SMC serves different functions during development of the intestine in the rat, but is primarily a secreted product in the adult animal.
Title: Expression and localization of Muc4/sialomucin complex (SMC) in the adult and developing rat intestine: implications for Muc4/SMC function.
Muc4/SMC transcription is upregulated by PEA3, which may contribute to the metastatic potential of mammary tumors
Title: PEA3 transactivates the Muc4/sialomucin complex promoter in mammary epithelial and tumor cells.

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General gene information

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Markers

Muc4 (e-PCR), detects polymorphism
- UniSTS:239203

GDB:305493 (e-PCR)
- UniSTS:156411

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ErbB-2 class receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ErbB-2 class receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in digestive tract development	IEP Inferred from Expression Pattern more info	PubMed
involved_in estrous cycle	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in lactation	IEP Inferred from Expression Pattern more info	PubMed
involved_in maintenance of gastrointestinal epithelium	ISO Inferred from Sequence Orthology more info
involved_in mammary gland development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of T cell mediated cytotoxicity directed against tumor cell target	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in post-embryonic camera-type eye development	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cytokine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mucin-4

Names: ASGP; MUC-4; ascites sialoglycoprotein; pancreatic adenocarcinoma mucin; pre-sialomucin complex; sialomucin ascites sialoglycoprotein-1; sialomucin complex; testis mucin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.