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    Eif4a2 eukaryotic translation initiation factor 4A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303831, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eif4a2provided by RGD
    Official Full Name
    eukaryotic translation initiation factor 4A2provided by RGD
    Primary source
    RGD:1309225
    See related
    EnsemblRapid:ENSRNOG00000001815 AllianceGenome:RGD:1309225
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP hydrolysis activity and translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation and negative regulation of RNA-dependent RNA polymerase activity. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with hypotonia and speech delay. Orthologous to human EIF4A2 (eukaryotic translation initiation factor 4A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 2426.5), Brain (RPKM 2289.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eif4a2 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (91268730..91276738, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (77764126..77770810, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (81373047..81379680, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene adiponectin, C1Q and collagen domain containing Neighboring gene replication factor C subunit 4 Neighboring gene small nucleolar RNA SNORA4 Neighboring gene small nucleolar RNA SNORA63 Neighboring gene small nucleolar RNA SNORA81 Neighboring gene small nucleolar RNA SNORA63 Neighboring gene small nucleolar RNA, C/D box 2 Neighboring gene cyclin B1 interacting protein 1, pseudogene 4 Neighboring gene H3.3 histone A, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The diverse roles of the eIF4A family: you are the company you keep. Lu WT, et al. Biochem Soc Trans, 2014 Feb. PMID 24450646
    2. Human eukaryotic initiation factor 4AII associates with hepatitis C virus NS5B protein in vitro. Kyono K, et al. Biochem Biophys Res Commun, 2002 Apr 5. PMID 11922617
    3. Intracellular localization and unique conserved sequences of three small nucleolar RNAs. Selvamurugan N, et al. Nucleic Acids Res, 1997 Apr 15. PMID 9092667, Free PMC Article
    4. mRNA helicases: the tacticians of translational control. Parsyan A, et al. Nat Rev Mol Cell Biol, 2011 Apr. PMID 21427765
    5. Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart. Martins-Marques T, et al. Mol Cell Proteomics, 2015 Nov. PMID 26316108, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94588

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasmic translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of RNA-dependent RNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic initiation factor 4A-II
    Names
    ATP-dependent RNA helicase eIF4A-2
    eIF-4A-II
    eIF4A-II
    eukaryotic translation initiation factor 4A
    protein synthesis initiation factor 4AII
    NP_001008336.1
    XP_006248596.1
    XP_006248597.1
    XP_063126554.1
    XP_063126555.1
    XP_063126556.1
    XP_063126558.1
    XP_063126559.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008335.1 → NP_001008336.1  eukaryotic initiation factor 4A-II

      See identical proteins and their annotated locations for NP_001008336.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085859
      UniProtKB/Swiss-Prot
      Q5RKI1
      UniProtKB/TrEMBL
      A6HFS9, A6JS30
      Related
      ENSRNOP00000002484.7, ENSRNOT00000002484.8
      Conserved Domains (1) summary
      PTZ00424
      Location:21 → 407
      PTZ00424; helicase 45; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      91268730..91276738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270484.1 → XP_063126554.1  eukaryotic initiation factor 4A-II isoform X1

      UniProtKB/TrEMBL
      A6HFS9

    2. XM_063270488.1 → XP_063126558.1  eukaryotic initiation factor 4A-II isoform X4

      UniProtKB/TrEMBL
      A6HFS9

    3. XM_063270485.1 → XP_063126555.1  eukaryotic initiation factor 4A-II isoform X2

      UniProtKB/Swiss-Prot
      Q5RKI1
      UniProtKB/TrEMBL
      A6HFS9, A6JS30

    4. XM_006248534.5 → XP_006248596.1  eukaryotic initiation factor 4A-II isoform X1

      See identical proteins and their annotated locations for XP_006248596.1

      UniProtKB/TrEMBL
      A6HFS9
      Conserved Domains (1) summary
      PTZ00424
      Location:9 → 408
      PTZ00424; helicase 45; Provisional

    5. XM_063270486.1 → XP_063126556.1  eukaryotic initiation factor 4A-II isoform X4

      UniProtKB/TrEMBL
      A6HFS9
      Related
      ENSRNOP00000074545.3, ENSRNOT00000089294.3

    6. XM_006248535.5 → XP_006248597.1  eukaryotic initiation factor 4A-II isoform X3

      See identical proteins and their annotated locations for XP_006248597.1

      UniProtKB/TrEMBL
      A6HFS9
      Conserved Domains (1) summary
      PTZ00424
      Location:9 → 361
      PTZ00424; helicase 45; Provisional

    7. XM_063270489.1 → XP_063126559.1  eukaryotic initiation factor 4A-II isoform X5

      UniProtKB/TrEMBL
      A0A8L2PZP8

    RNA

    1. XR_358387.5 RNA Sequence

    2. XR_010055952.1 RNA Sequence

    3. XR_005491022.2 RNA Sequence

    4. XR_358388.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RKI1.1 GenPept UniProtKB/Swiss-Prot:Q5RKI1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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