Alcam activated leukocyte cell adhesion molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Alcamprovided by RGD
Official Full Name: activated leukocyte cell adhesion moleculeprovided by RGD
Primary source: RGD:619972
See related: EnsemblRapid:ENSRNOG00000001989 AllianceGenome:RGD:619972
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in axon extension involved in axon guidance; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and retinal ganglion cell axon guidance. Predicted to act upstream of or within motor neuron axon guidance. Predicted to be located in several cellular components, including external side of plasma membrane; immunological synapse; and neuronal cell body. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane. Orthologous to human ALCAM (activated leukocyte cell adhesion molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 640.6), Brain (RPKM 308.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q21

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (61804932..62005250)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (48336123..48536296)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (50780735..50985083)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiRNA-192-5p-targeted activated leukocyte cell adhesion molecule improved inflammatory injury of neonatal necrotizing enterocolitis.
Title: MiRNA-192-5p-targeted activated leukocyte cell adhesion molecule improved inflammatory injury of neonatal necrotizing enterocolitis.
the modulatory roles of ALCAM in the excitatory synaptic transmission and plasticity in the rat spinal dorsal horn
Title: Activated leukocyte cell adhesion molecule is involved in excitatory synaptic transmission and plasticity in the rat spinal dorsal horn.
ALCAM synergizes with nerve growth factor to induce neuronal differentiation, raising the possibility that it functions not only as an adhesion molecule but also in the modulation of growth factor signaling in the nervous system
Title: Activated leukocyte cell adhesion molecule modulates neurotrophin signaling.
The immunolocalisation of the stem cell-specific markers Notch-1, Delta, CD105 and CD166 was studied in rat femoral head articular cartilage. Corticosteroid (methylprednisolone) treatment was found to decrease the activity of these markers.
Title: The effect of systemic corticosteroid treatment on the immunolocalisation of Notch-1, Delta, CD105 and CD166 in rat articular cartilage.
Localization of ALCAM specifically at cell-cell junctions in endothelial cells supported its role in transendothelial migration
Title: Activated leukocyte cell adhesion molecule is a component of the endothelial junction involved in transendothelial monocyte migration.

Submit: New GeneRIF Correction

General gene information

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Markers

RH138841 (e-PCR)
- UniSTS:220928

AU026994 (e-PCR)
- UniSTS:113733

BE119309 (e-PCR)
- UniSTS:249157

BE116234 (e-PCR)
- UniSTS:248457

RH139064 (e-PCR)
- UniSTS:221150

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in axon extension involved in axon guidance	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in motor neuron axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within motor neuron axon guidance	ISO Inferred from Sequence Orthology more info
involved_in neuron projection extension	ISS Inferred from Sequence or Structural Similarity more info
involved_in retinal ganglion cell axon guidance	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of T cell receptor complex	IEA Inferred from Electronic Annotation more info
part_of T cell receptor complex	ISO Inferred from Sequence Orthology more info
part_of T cell receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	IEA Inferred from Electronic Annotation more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: CD166 antigen

Names: HB2; KG-CAM; SB-10 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431413.1 → NP_001418342.1 CD166 antigen isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A0A8I5ZQS5, A6IQS3
NM_001431414.1 → NP_001418343.1 CD166 antigen isoform 3 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A0A8L2UHD3
NM_031753.3 → NP_113941.1 CD166 antigen isoform 2 precursor

See identical proteins and their annotated locations for NP_113941.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

O35112, O55172

Conserved Domains (5) summary

smart00406
Location:38 → 113

IGv; Immunoglobulin V-Type

smart00410
Location:255 → 329

IG_like; Immunoglobulin like

pfam08205
Location:137 → 231

C2-set_2; CD80-like C2-set immunoglobulin domain

pfam13927
Location:256 → 313

Ig_3; Immunoglobulin domain

cl11960
Location:415 → 488

Ig; Immunoglobulin domain