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    Ramac RNA guanine-7 methyltransferase activating subunit [ Mus musculus (house mouse) ]

    Gene ID: 67148, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ramacprovided by MGI
    Official Full Name
    RNA guanine-7 methyltransferase activating subunitprovided by MGI
    Primary source
    MGI:MGI:1914398
    See related
    Ensembl:ENSMUSG00000038646 AllianceGenome:MGI:1914398
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RAM; Rammet; Fam103a1; 2410047I02Rik; 2610204K14Rik
    Summary
    Predicted to enable RNA binding activity and enzyme activator activity. Predicted to be involved in 7-methylguanosine mRNA capping. Predicted to be located in nucleus. Predicted to be part of mRNA cap methyltransferase RNMT:RAMAC complex and mRNA capping enzyme complex. Is expressed in embryo. Orthologous to several human genes including RAMAC (RNA guanine-7 methyltransferase activating subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 29.5), CNS E18 (RPKM 25.4) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Ramac in Genome Data Viewer
    Location:
    7 D3; 7 45.71 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (81412701..81419238)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (81762953..81769490)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42400 Neighboring gene G2/M-phase specific E3 ubiquitin ligase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6568 Neighboring gene RIKEN cDNA 3110040N11 gene Neighboring gene STARR-positive B cell enhancer ABC_E4944 Neighboring gene BTB domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables molecular function activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in 7-methylguanosine mRNA capping ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in RNA 5'-cap (guanine-N7)-methylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of mRNA cap methyltransferase RNMT:RAMAC complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mRNA cap methyltransferase RNMT:RAMAC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of mRNA capping enzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of mRNA capping enzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mRNA capping enzyme complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    RNA guanine-N7 methyltransferase activating subunit
    Names
    RNMT actvating mRNA cap methylating subunit
    RNMT-activating mRNA cap methylating subunit
    RNMT-activating mRNA cap methyltransferase subunit
    RNMT-activating mini protein
    family with sequence similarity 103, member A1
    protein FAM103A1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025997.2NP_080273.1  RNA guanine-N7 methyltransferase activating subunit

      See identical proteins and their annotated locations for NP_080273.1

      Status: PROVISIONAL

      Source sequence(s)
      AC102077, AC130538
      Consensus CDS
      CCDS21406.1
      UniProtKB/Swiss-Prot
      Q3TV69, Q9CQY2, Q9CWI1
      Related
      ENSMUSP00000039065.5, ENSMUST00000042166.11
      Conserved Domains (1) summary
      pfam15320
      Location:1087
      RAM; mRNA cap methylation, RNMT-activating mini protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      81412701..81419238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)