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    Hnrnpf heterogeneous nuclear ribonucleoprotein F [ Mus musculus (house mouse) ]

    Gene ID: 98758, updated on 27-Nov-2024

    Summary

    Official Symbol
    Hnrnpfprovided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Fprovided by MGI
    Primary source
    MGI:MGI:2138741
    See related
    Ensembl:ENSMUSG00000042079 AllianceGenome:MGI:2138741
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hnrpf; 4833420I20Rik
    Summary
    Predicted to enable TBP-class protein binding activity and single-stranded RNA binding activity. Predicted to be involved in regulation of RNA splicing. Is active in synapse. Is expressed in branchial arch; central nervous system; and sensory organ. Used to study renal glycosuria. Orthologous to human HNRNPF (heterogeneous nuclear ribonucleoprotein F). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 143.4), liver E14.5 (RPKM 122.6) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Hnrnpf in Genome Data Viewer
    Location:
    6 F1; 6 55.66 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (117877301..117902583)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (117900340..117925622)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 239 Neighboring gene STARR-seq mESC enhancer starr_17123 Neighboring gene predicted gene, 38883 Neighboring gene predicted gene, 38882 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:117850148-117850426 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:117850781-117850973 Neighboring gene RIKEN cDNA 4933440N22 gene Neighboring gene STARR-positive B cell enhancer ABC_E1069 Neighboring gene STARR-seq mESC enhancer starr_17127 Neighboring gene STARR-seq mESC enhancer starr_17129 Neighboring gene FXYD domain-containing ion transport regulator 4 Neighboring gene STARR-seq mESC enhancer starr_17131 Neighboring gene predicted gene, 38884 Neighboring gene Lasp1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC36971, MGC101981

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables TBP-class protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables TBP-class protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of RNA splicing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IEA
    Inferred from Electronic Annotation
    more info
     
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoprotein F
    Names
    hnRNP F

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166427.1NP_001159899.1  heterogeneous nuclear ribonucleoprotein F

      See identical proteins and their annotated locations for NP_001159899.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same protein.
      Source sequence(s)
      BC047346, CJ094336, CX218091
      Consensus CDS
      CCDS20467.1
      UniProtKB/Swiss-Prot
      Q5FWK2, Q8BVU8, Q8K2U9, Q8R0E7, Q9Z2X1
      Related
      ENSMUSP00000137632.2, ENSMUST00000180020.8
      Conserved Domains (4) summary
      pfam08080
      Location:255290
      zf-RNPHF; RNPHF zinc finger
      cd12506
      Location:289363
      RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12729
      Location:1088
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    2. NM_001166428.1NP_001159900.1  heterogeneous nuclear ribonucleoprotein F

      See identical proteins and their annotated locations for NP_001159900.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same protein.
      Source sequence(s)
      BC047346, BY774552, CA539382, CJ054614, CX218091
      Consensus CDS
      CCDS20467.1
      UniProtKB/Swiss-Prot
      Q5FWK2, Q8BVU8, Q8K2U9, Q8R0E7, Q9Z2X1
      Conserved Domains (4) summary
      pfam08080
      Location:255290
      zf-RNPHF; RNPHF zinc finger
      cd12506
      Location:289363
      RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12729
      Location:1088
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    3. NM_001166429.1NP_001159901.1  heterogeneous nuclear ribonucleoprotein F

      See identical proteins and their annotated locations for NP_001159901.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same protein.
      Source sequence(s)
      BC047346, BY774552, CK389060, CX218091
      Consensus CDS
      CCDS20467.1
      UniProtKB/Swiss-Prot
      Q5FWK2, Q8BVU8, Q8K2U9, Q8R0E7, Q9Z2X1
      Conserved Domains (4) summary
      pfam08080
      Location:255290
      zf-RNPHF; RNPHF zinc finger
      cd12506
      Location:289363
      RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12729
      Location:1088
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    4. NM_001166430.1NP_001159902.1  heterogeneous nuclear ribonucleoprotein F

      See identical proteins and their annotated locations for NP_001159902.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same protein.
      Source sequence(s)
      AU079872, BC047346, CJ048596, CJ169112, CX218091
      Consensus CDS
      CCDS20467.1
      UniProtKB/Swiss-Prot
      Q5FWK2, Q8BVU8, Q8K2U9, Q8R0E7, Q9Z2X1
      Conserved Domains (4) summary
      pfam08080
      Location:255290
      zf-RNPHF; RNPHF zinc finger
      cd12506
      Location:289363
      RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12729
      Location:1088
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    5. NM_001166431.1NP_001159903.1  heterogeneous nuclear ribonucleoprotein F

      See identical proteins and their annotated locations for NP_001159903.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same protein.
      Source sequence(s)
      BC047346, CJ048596, CJ094704, CX218091
      Consensus CDS
      CCDS20467.1
      UniProtKB/Swiss-Prot
      Q5FWK2, Q8BVU8, Q8K2U9, Q8R0E7, Q9Z2X1
      Related
      ENSMUSP00000130023.3, ENSMUST00000163168.9
      Conserved Domains (4) summary
      pfam08080
      Location:255290
      zf-RNPHF; RNPHF zinc finger
      cd12506
      Location:289363
      RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12729
      Location:1088
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    6. NM_001166432.1NP_001159904.1  heterogeneous nuclear ribonucleoprotein F

      See identical proteins and their annotated locations for NP_001159904.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same protein.
      Source sequence(s)
      BC047346, CF163622, CX218091
      Consensus CDS
      CCDS20467.1
      UniProtKB/Swiss-Prot
      Q5FWK2, Q8BVU8, Q8K2U9, Q8R0E7, Q9Z2X1
      Related
      ENSMUSP00000126817.2, ENSMUST00000167182.8
      Conserved Domains (4) summary
      pfam08080
      Location:255290
      zf-RNPHF; RNPHF zinc finger
      cd12506
      Location:289363
      RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12729
      Location:1088
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    7. NM_133834.2NP_598595.1  heterogeneous nuclear ribonucleoprotein F

      See identical proteins and their annotated locations for NP_598595.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript. Variants 1-7 encode the same protein.
      Source sequence(s)
      AK076478, BC047346, CJ048596, CX218091
      Consensus CDS
      CCDS20467.1
      UniProtKB/Swiss-Prot
      Q5FWK2, Q8BVU8, Q8K2U9, Q8R0E7, Q9Z2X1
      Related
      ENSMUSP00000045048.8, ENSMUST00000035493.14
      Conserved Domains (4) summary
      pfam08080
      Location:255290
      zf-RNPHF; RNPHF zinc finger
      cd12506
      Location:289363
      RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12729
      Location:1088
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      117877301..117902583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506829.5XP_006506892.1  heterogeneous nuclear ribonucleoprotein F isoform X1

      See identical proteins and their annotated locations for XP_006506892.1

      UniProtKB/Swiss-Prot
      Q5FWK2, Q8BVU8, Q8K2U9, Q8R0E7, Q9Z2X1
      Conserved Domains (4) summary
      pfam08080
      Location:255290
      zf-RNPHF; RNPHF zinc finger
      cd12506
      Location:289363
      RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12729
      Location:1088
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins