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    Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [ Mus musculus (house mouse) ]

    Gene ID: 108147, updated on 9-Dec-2024

    Summary

    Official Symbol
    Aticprovided by MGI
    Official Full Name
    5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolaseprovided by MGI
    Primary source
    MGI:MGI:1351352
    See related
    Ensembl:ENSMUSG00000026192 AllianceGenome:MGI:1351352
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610509C24Rik
    Summary
    Enables IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Involved in purine ribonucleoside monophosphate biosynthetic process. Acts upstream of or within cellular response to interleukin-7. Located in mitochondrion. Is expressed in several structures, including alimentary system; heart; nervous system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 26.0), limb E14.5 (RPKM 25.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Atic in Genome Data Viewer
    Location:
    1 C3; 1 36.03 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (71596315..71618562)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (71557156..71579403)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family A member 12 Neighboring gene predicted gene, 39659 Neighboring gene STARR-seq mESC enhancer starr_01238 Neighboring gene STARR-seq mESC enhancer starr_01239 Neighboring gene STARR-seq mESC enhancer starr_01240 Neighboring gene predicted gene 6947 Neighboring gene STARR-seq mESC enhancer starr_01242 Neighboring gene STARR-positive B cell enhancer ABC_E5770 Neighboring gene fibronectin 1 Neighboring gene STARR-seq mESC enhancer starr_01248 Neighboring gene STARR-seq mESC enhancer starr_01250 Neighboring gene apolipoprotein L 7d

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables IMP cyclohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables IMP cyclohydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables IMP cyclohydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in 'de novo' AMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in 'de novo' AMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in 'de novo' IMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in 'de novo' IMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in 'de novo' IMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in 'de novo' XMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in 'de novo' XMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in GMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in GMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in animal organ regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in brainstem development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to interleukin-7 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cerebellum development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dihydrofolate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dihydrofolate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tetrahydrofolate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tetrahydrofolate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    bifunctional purine biosynthesis protein ATIC
    Names
    AICAR transformylase/inosine monophosphate cyclohydrolase
    bifunctional purine biosynthesis protein PURH
    NP_080471.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026195.3NP_080471.2  bifunctional purine biosynthesis protein ATIC

      See identical proteins and their annotated locations for NP_080471.2

      Status: VALIDATED

      Source sequence(s)
      AK010611, AK012074, CJ178786
      Consensus CDS
      CCDS15030.1
      UniProtKB/Swiss-Prot
      Q3UTQ3, Q80UH0, Q8BPF0, Q8BQV9, Q9CRI1, Q9CWJ9, Q9CZW9
      Related
      ENSMUSP00000027384.6, ENSMUST00000027384.6
      Conserved Domains (3) summary
      PRK07106
      Location:203592
      PRK07106; 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional
      COG0138
      Location:3592
      PurH; AICAR transformylase/IMP cyclohydrolase PurH [Nucleotide transport and metabolism]
      cd01421
      Location:5193
      IMPCH; Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      71596315..71618562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)