Alkbh7 alkB homolog 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Alkbh7provided by MGI
Official Full Name: alkB homolog 7provided by MGI
Primary source: MGI:MGI:1913650
See related: Ensembl:ENSMUSG00000002661 AllianceGenome:MGI:1913650
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Abh7; Spata11; 2310045B01Rik; 2510008E23Rik
Summary: Predicted to enable metal ion binding activity. Involved in fatty acid metabolic process and regulation of lipid storage. Located in mitochondrial matrix. Is expressed in brown fat. Used to study obesity. Orthologous to human ALKBH7 (alkB homolog 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 71.0), ovary adult (RPKM 30.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 D; 17 29.61 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (57304339..57306340)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (56997339..56999340)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ALKBH7 mediates necrosis via rewiring of glyoxal metabolism.
Title: ALKBH7 mediates necrosis via rewiring of glyoxal metabolism.
results uncover an in vivo role for ALKBH7 in mediating a sexually dimorphic tissue response to alkylation damage that could influence individual responses to chemotherapies based upon alkylating agents.
Title: ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage.
the first direct demonstration that murine Alkbh7 is a mitochondrial resident protein involved in fatty acid metabolism and the development of obesity.
Title: Deletion of mouse Alkbh7 leads to obesity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Markers

D17Wsu160e (e-PCR), detects polymorphism
- UniSTS:142172

RH136298 (e-PCR)
- UniSTS:210290

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables 2-oxoglutarate-dependent dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrial membrane permeability involved in programmed necrotic cell death	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane permeability involved in programmed necrotic cell death	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial

Names: alkB, alkylation repair homolog 7; alkylated DNA repair protein alkB homolog 7; probable alpha-ketoglutarate-dependent dioxygenase ABH7; spermatogenesis associated 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025538.3 → NP_079814.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial isoform 1 precursor

See identical proteins and their annotated locations for NP_079814.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC073683, AK009812, AK010930

Consensus CDS

CCDS28921.1

UniProtKB/Swiss-Prot

Q8K1H3, Q9CY41, Q9D6Z0, Q9D942

Related

ENSMUSP00000002737.7, ENSMUST00000002737.7

Conserved Domains (1) summary

cl21496
Location:33 → 200

2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily
NM_027372.1 → NP_081648.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial isoform 2

See identical proteins and their annotated locations for NP_081648.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. The resulting isoform (2) lacks an internal protein segment compared to isoform 1.

Source sequence(s)

AC073683, AK010930

Consensus CDS

CCDS57105.1

UniProtKB/Swiss-Prot

Q9D6Z0

Related

ENSMUSP00000073775.8, ENSMUST00000074141.14

Conserved Domains (1) summary

cl21496
Location:73 → 139

2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily